{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics","Multiomics"],"center_name":["Stem Cell Biology and Cellular Engineering, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA141137"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:22221451"],"long_description":["Long-term culture associated changes need to be considered for quality control of cell preparations – especially in cellular therapy. Here we describe a simple method to track cellular aging based on continuous DNA-methylation changes at six specific CpG sites. This epigenetic signature can be used as a biomarker for various cell types to predict the state of cellular aging with regard to the number of passages or days of in vitro culture. Overall design: 8 samples of human dermal fibroblasts. 4 samples of mesenchymal stem cells (MSC) from human adipose tissue."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Homo sapiens","description":"Cellular aging can be monitored by DNA-methylation changes at specific CpG sites","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA141137","cross_references":{"GEO":["GSE29661"],"taxon":["9606"],"PubMed":["22221451"]}}