ENAGenomicsMolecular Biology, Life Science, Dongguk Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA145235Homo sapiensHuman lactoferrin (LF) is a multifunctional protein involved in immunomodulation, cell growth, and differentiation. In addition to the secreted form (sLF), an alternatively spliced form (ΔLF) that lacks the signal sequence and downregulated in cancer was found. This study was carried out to identify and compare signaling networks provoked by the two LF isoforms. To do this, the two forms were overexpressed in HEK293 cells using the flp-in/tet-on system and genome-wide expression analysis of 18,367 genes was conducted. Overall design: Secreted form (sLF) or alternatively spliced form (ΔLF) were overexpressed in HEK293 cells using the flp-in/tet-on system and genome-wide expression analysis of 18,367 genes was conducted.ENA293T Cell, 293 Cells, Materials, Clo, Slf, SLF, Human Embryonic Kidney Cell Line 293, Gene, HEK293 Cell, contrasted, 293T, CG5406, Gene Expression Profilings, Transcript Expression Analysis, mRNA Differential Displays, Lfcin-H, CG34418, Gene Expression Pattern Analysis, slf, Gene Expression Monitorings, DmelCG34418, CG5256, HEK 293, Analysis, Profilings, 3.4.21.-, Genetic, Analyses, SF, Transcriptomics, Kitl, Transcript Expression, Transcriptome Analysis, Otf9., Monitoring, Gene Expression Analysis, Con, Growth-inhibiting protein 12, 293T Cells, blz, RhoGEF, Expression Analyses, Sl, LF, Kaliocin-1, 293 Cell, Talalactoferrin, Profiling, Lactoferricin-H, oct-9, Transcriptome, GIG12, Dmel_CG5406, Monitorings, Lactoferrin, Human Kidney Cell Line 293, Cistrons, HEK 293 Cell, Cell, Gene Expression, Differential Display, transcription profiling, Lactotransferrin, Transcript Expression Analyses, sequence, SIF, Sif, Genetic Materials, mRNA Differential Display, gene expression profiling, Genetic Material, Dmel_CG32414, Gene Expression Monitoring, Transcriptome Profiling, mast cell growth factor, mRNA, Transcriptome Profilings, HEK293, INSDC_feature:gene, Differential Displays, Transcriptome Analyses, primary structure of sequence macromolecule, HEK 293 Cell Line, Kitlg, Gene Expression Analyses, HEK 293 Cells, Brn4, Lactoferroxin-C, Material, Lactoferroxin-A, Lactoferroxin-B, OTF-9, Mgf, Cells, HEK, Brn-4, Cistron, Expression Analysis, SCF, CG32414, GbHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManfalseHomo sapiensGene expression profiling in HEK293 cells overexpressed lactoferrin gene that has the signal sequence (sLF) or not (ΔLF)2025-09-242014-02-11PRJNA145235GSE318789606