{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR504/SRR504970/SRR504970.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR327/SRR327604/SRR327604.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR327/SRR327605/SRR327605.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR504/SRR504969/SRR504969.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics","Multiomics"],"center_name":["ETH Zurich"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA146069"],"scientific_name":["Drosophila melanogaster"],"tag":["xref:PubMed:22579285"],"long_description":["In this study we provide evidence that Hsp90 binds chromatin at specific sites close to several TSS in Drosophila S2 cell line. In addition of finding a preference for stalled promoter regions of annotated genes, we uncover many intergenic Hsp90 binding sites coinciding with non-annotated transcription start sites. Interestingly, this set includes promoters for primary transcripts of microRNA genes, thereby expanding the scope of Hsp90 to transcriptional control of many genes. We finally conclude that Hsp90 contacts NelfE and thus regulates pol II pausing. Overall design: Our Dataset comprises of 1 ChIP-seq sample using chromatin from S2 cells which was immunoprecipitated, using antibodies against Drosophila Hsp90. The two biological replicates are submitted along with the input replicates."],"repository":["ENA"],"description_synonyms":["Shock, Gene., Temperature, Gene Expressions, Circulatory, protein complex, Proteins, Gene, proteins, Circulatory Failure, protein, protein-containing complex, Expressions, Failure, Hypovolemic Shock, Circulatory Collapse, Collapse, Protein Gene Products, Impact, Gene Proteins, Environmental Impact, Environmental, Hypovolemic, protein polypeptide chains, Temperatures, native protein, natural protein, polypeptide chain, Hot, Protein, Gene Products, Environments, Heat, Hot Temperatures, Impacts, Expression, Environmental Impacts, protein aggregate"],"name_synonyms":["fruit fly, Drosophila melanogasters., Drosophila, Sophophora melanogaster, melanogaster, D. melanogaster, Drosophila melangaster"],"additional_accession":[]},"is_claimable":false,"name":"Drosophila melanogaster","description":"Heat-shock protein 90 globally targets paused promoters and regulates environment-induced gene expression","dates":{"last_updated":"2025-09-24","first_public":"2013-05-31"},"accession":"PRJNA146069","cross_references":{"GEO":["GSE31226"],"taxon":["7227"],"PubMed":["22579285"]}}