ENAGenomicsMultiomicsWeissman lab, Pathology, Stanford Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA146789Homo sapiensIn the human hematopoietic system, aging is associated with decreased bone marrow cellularity, decreased adaptive immune system function, and increased incidence of anemia and other hematological disorders and malignancies. Recent studies in mice suggest that changes within the hematopoietic stem cell (HSC) population during aging contribute significantly to the manifestation of these age-associated hematopoietic pathologies. While the mouse HSC population has been shown to change both quantitatively and functionally with age, changes in the human HSC and progenitor cell populations during aging have not yet been characterized. Gene expression profiling revealed that aged human HSC transcriptionally up-regulate genes associated with cell cycle, myeloid lineage specification, and myeloid malignancies. These age-associated alterations in the frequency, function, and gene expression profile of human HSC are significantly similar to those changes observed in mouse HSC, suggesting that hematopoietic aging is an evolutionarily conserved process. Overall design: In order to elucidate the properties of an aged human hematopoietic system that may predispose to age-associated hematopoietic dysfunction, we evaluated HSC and other hematopoietic progenitor populations from healthy, hematologically normal young and elderly human bone marrow samples. We found that aged human HSC increase in frequency, are less quiescent, and exhibit myeloid-biased differentiation potential compared to young HSC.xref:PubMed:22123971ENAHematopoietic Progenitor Cell, Hematopoietic Colony-Forming, Yellow Marrow, Hematopoietic Colony-Forming Units, Hematopoietic, Hematopoietic Progenitor, human being, Man (Taxonomy), medullary bone, medulla of bone, Unit, Modern, Progenitor Cells, Colony-Forming Units, Stem Cells, Progenitor Cell, Colony Forming Units, Hematopoietic Stem Cell, human, Cell, Red Marrow, Hematopoietic Progenitor Cells, Human, Colony-Forming Unit, Homo sapiens, medulla ossium, Hematopoietic Stem, Stem Cell, Modern Man, Marrow, medulla ossea, Cells, Units, Red, Yellow, Man, Bone, Hematopoietic Colony-Forming Unit, humans, Hematopoietic.Human, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManfalseHomo sapiensExpression data from human bone marrow hematopoietic stem cells2025-09-242014-02-11PRJNA146789GSE32719960622123971