ENAGenomicsMultiomicsMicroarray Core, Center for Functional Genomics, SUNY-University at Albanyhttps://www.ebi.ac.uk/ena/browser/view/PRJNA146891Mus musculusThrombospondin 1 (TSP-1) is an anti-angiogenic matricellular protein with regulatory functions in inflammation and cancer. The type 1 repeats (TSR) domains of TSP-1 have been shown to interact with a wide range of proteins that result in the anti-angiogenic and anti-tumor properties of TSP-1. To evaluate potential therapeutic effects of TSRs in inflammatory bowel disease, we conducted clinical, histological and gene microarray analyses on a mouse model of induced colitis. We used Affymetrix GeneChips to determine the changes in the genetic profile underlying TSR-treatment coincident with induction of colitis using DSS. We identified differentially expressed genes among the treatment groups. Overall design: Using DSS (dextran sulfate sodium) to induce colitis, wild-type mice were simultaneously injected with either saline or one form of TSP-1 derived peptides, containing either the three domains of the TSR (3TSR), the two last domains (TSR2), or TSR2 with the RFK sequence (TSR2+RFK). Wt mice drinking water only was used as reference.xref:PubMed:22509329ENAMGC130048, gamma sarcoglycan, SGCG_HUMAN, Bowel Diseases, Genetic, DMDA1, 35 kDa dystrophin-associated glycoprotein, IBD, Profile, Thrombospondin-1, SG-gamma, A4, INFLAMM BOWEL DIS, Genetic., Profiles, gamma (35kDa dystrophin-associated glycoprotein), Inflammatory Bowel Disease, TYPE, SGCG, LGMD2C, DAGA4, Inflammatory Bowel Diseases, Genotype Profile, DMDA, Genotype, 35kD dystrophin-associated glycoprotein, SCARMD2, inflammatory bowel disease, 35DAG, Inflammatory bowel disease, Genetic Profiles, gamma-sarcoglycan, sarcoglycan, autoimmune bowel disorder, Genotype Profiles, MAM, gamma-SG, Inflammatory, SCG3Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscarisfalseMus musculusThrombospondin-1 type 1 repeats in a model of inflammatory bowel disease: genetic profile and therapeutic effects2025-09-242014-08-28PRJNA146891GSE326971009022509329