ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402458/SRR402458.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402448/SRR402448.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402468/SRR402468.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402455/SRR402455.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402445/SRR402445.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402452/SRR402452.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402462/SRR402462.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402450/SRR402450.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402465/SRR402465.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402460/SRR402460.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402463/SRR402463.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402453/SRR402453.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402456/SRR402456.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402446/SRR402446.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402469/SRR402469.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402466/SRR402466.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402461/SRR402461.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402454/SRR402454.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402471/SRR402471.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402459/SRR402459.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402467/SRR402467.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402447/SRR402447.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402449/SRR402449.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402457/SRR402457.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402470/SRR402470.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402464/SRR402464.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR402/SRR402451/SRR402451.fastq.gzprimaryOK200GenomicsMultiomicsNerbonne, Developmental Biology, Washington University in St Louishttps://www.ebi.ac.uk/ena/browser/view/PRJNA152727Mus musculusA molecular and bioinformatic pipeline permitting comprehensive analysis and quantification of myocardial miRNA and mRNA expression with next-generation sequencing was developed and the impact of enhanced PI3Kalpha signaling on the myocardial transcriptome signature of pressure overload-induced pathological hypertrophy was explored. Overall design: miRNA and mRNA-Seq were carried out in four groups of mouse LV samples: WT sham, WT+TAC, caPI3Kalpha sham, caPI3Kalpha+TACxref:PubMed:22580345ENAMus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscarisHeart, RNA, Serine|threonine protein kinase PIK3CA, biological signaling, Polyadenylated, cardiomegaly, stRNA, 2.7.1.153, Small Temporal RNA, Heart Hypertrophy, myocardial hypertrophy, Messenger RNA, Cardiac., Primary, Enlargement, heart hypertrophy, Small, 2.7.11.1, Phosphatidylinositol 4, Cardiac, Micro RNA, PI3-kinase subunit alpha, Messenger, Poly(A)+ mRNA, INSDC_feature:mRNA, p110alpha, Cardiac Hypertrophies, Polyadenylated RNA, PI3Kalpha, Heart Hypertrophies, pre-miRNA, 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, Non Polyadenylated, Hypertrophies, Hypertrophy, pri miRNA, Polyadenylated Messenger RNA, miRNAs, Poly(A)+ RNA, Phosphoinositide-3-kinase catalytic alpha polypeptide, Small Temporal, Non Polyadenylated mRNA, protein_coding_transcript, Micro, mRNA, Poly(A) Tail, Heart Enlargement, Temporal RNA, Polyadenylated Messenger, Non-Polyadenylated, messenger RNA, Primary MicroRNA, PI3K-alpha, miRNA, Primary miRNA, INSDC_feature:ncRNA, pri-miRNA, Non-Polyadenylated mRNA, signalling, Cardiac Hypertrophy, template RNA, Enlarged, signalling process, Enlarged Heart, PtdIns-3-kinase subunit p110-alpha, signaling process, MicroRNA, PtdIns-3-kinase subunit alpha, enlarged heart, Polyadenylated mRNA, pre miRNA, Poly(A) RNA, single organism signalingfalseMus musculusCombined miRNA and mRNA Sequencing Identifies Protective Transcriptional Signature of Enhanced PI3Kalpha Signaling in Cardiac Hypertrophy2025-09-242013-05-31PRJNA152727GSE353501009022580345