ENAGenomicsOntario Cancer Institutehttps://www.ebi.ac.uk/ena/browser/view/PRJNA153405Homo sapiensxref:PubMed:22624715Genome wide DNA methylation profiling of colon adenocarcinoma cell line HCT116 wild type and with a genetic disruption of DNMT3B and DNMT1 (DKO). The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. For this study, we used two DKO subclones, DKO8 and DKO1, which retain approximately 45% and 5% of the HCT116 wild type global DNA methylation levels, respectively Overall design: Bisulphite converted DNA from the 3 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2ENAHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern Manprimary cancer, DNA methylation maintenance, Malignant Neoplasm, Malignancy, Epigenetic, Neoplasms, Benign Neoplasm, Benign Neoplasms, DNA Methylations, Cancers, DNA methylation, Tumor, Viabilities, Malignant, malignant tumor, Cell, Epigenomic, Malignant Neoplasms, Neoplasias, Cell Viabilities, MT, Benign, malignant neoplasm, Survival, Neoplasm, Cell., Malignancies, DNA, Epigenetics, Cell Viability, Methylations, Methylation, Neoplasia, Viability, Cancer, TumorsfalseHomo sapiensDNA methylation screening identifies driver epigenetic events of cancer cell survival.2025-09-242014-02-11PRJNA153405GSE36534960622624715