{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Dimitrios Spentzos, Medicine, Beth Israel Deaconess Medical Center"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA169853"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:38946948","xref:PubMed:23339462"],"long_description":["Osteosarcoma is a malignancy with variable outcomes that are not tightly aligned with chemotherapy response. Previous work has suggested a possible role for microRNAs (miRNAs) in determining the susceptibility of osteosarcomas to treatment but formal miRNA-based outcome models have not been reported. Formalin-fixed, paraffin-embedded (FFPE) specimens may be a unique approach for such studies in a rare malignancy. We used supervised principal components analysis and logistic regression to study survival and chemoresponse endpoints, and miRNA activity and gene set analysis algorithms to study miRNA regulatory networks using mRNA data. Our study also creates a paradigm for FFPE-based miRNA clinical biomarker research in rare tumors. Overall design: 5 unique pairs of diagnostic biopsy and surgical resection specimens were profiled. Paired samples are denoted in the Sample 'characteristics' field."],"repository":["ENA"],"description_synonyms":["Osteosarcoma of bone (disorder), Osteochondrosarcoma, Osteosarcoma of bone, RNA, human being, Osteogenic Sarcomas, Osteogenic sarcoma, Polyadenylated, Osteosarcoma - disorder, Modern, Messenger RNA, Tumor, Osteogenic, Human, Osteogenic Sarcoma, Homo sapiens, Messenger, Poly(A)+ mRNA, [M]Osteosarcoma NOS, INSDC_feature:mRNA, NOS, Polyadenylated RNA, cytopathology, Osteoblastic osteosarcoma, Non Polyadenylated, Man, Osteosarcomas, Polyadenylated Messenger RNA, Skeletal sarcoma, Bone Sarcoma, Sarcomas, Poly(A)+ RNA, Sarcoma of the Bone, Non Polyadenylated mRNA, protein_coding_transcript, Man (Taxonomy), histopathology, mRNA, Poly(A) Tail, Polyadenylated Messenger, Sarcoma of Bone, Non-Polyadenylated, osteoid sarcoma, messenger RNA, Osteosarcoma, Biopsies., Osteoblastic sarcoma, Osseous Sarcoma, Non-Polyadenylated mRNA, human, bone tissue neoplasm, template RNA, Sarcoma, no ICD-O subtype, no ICD-O subtype (morphologic abnormality), Modern Man, Osteosarcoma Tumors, Osteosarcoma Tumor, biopsy, Polyadenylated mRNA, Poly(A) RNA, humans, osteosarcoma, Tumors"],"name_synonyms":["Human, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern Man"],"additional_accession":[]},"is_claimable":false,"name":"Homo sapiens","description":"mRNA profiling and clinical outcomes in human osteosarcoma (biopsy/resection pairs)","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA169853","cross_references":{"GEO":["GSE39057"],"taxon":["9606"],"PubMed":["38946948","23339462"]}}