ENAGenomicsMultiomicsNucleomics Core, VIBhttps://www.ebi.ac.uk/ena/browser/view/PRJNA170506Homo sapiensCidofovir is an acyclic nucleoside phosphonate with strong antiviral activity against a broad spectrum of DNA viruses. Although it has previously been shown that cidofovir exerts an antiproliferative effect on HPV positive cells by the induction of apoptosis, the exact mechanism of action remains to be unraveled. In order to study the activity of cidofovir against HPV, gene expression profiling was performed in cidofovir-treated and cidofovir-resistant HeLa, HaCaT, and PHK cells by means of microarrays (HG-U133 Plus 2, Affymetrix). Overall design: Controls (untreated HeLa, HaCaT, and PHK wild-type cells): 72h of growth. Cidofovir treated (50 µg/ml) HeLa, HaCaT, and PHK cells: 72h of growth. Cidofovir resistant cells (HeLa #52 and HaCaT #51): 72h of growth. All samples were performed in triplicates.xref:PubMed:26824416xref:PubMed:23702334ENATherapy, GS504, Profiling, Transcriptome, STK17, D330034O08, GS 504, GSD9A, PYKL, 1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine, Monitorings, phosphorylase B kinase activity, dephosphophosphorylase kinase activity, Gene, XLG2, (((1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, 1-((3-Hydroxy-2-phosphonylmethoxy)propyl)cytosine, Gene Expression Profilings, (R)-isomer, Gene Expression, Differential Display, Transcript Expression Analysis, transcription profiling, mRNA Differential Displays, Transcript Expression Analyses, Gene Expression Pattern Analysis, Cidofovir, 6330505C01Rik, resistance, Gene Expression Monitorings, Cell., (+-)-isomer, glycogen phosphorylase kinase activity, Analysis, Profilings, Phosphonic acid, Vistide, intrinsic catalyst activity, mRNA Differential Display, phosphorylase kinase, gene expression profiling, phosphorylase kinase (phosphorylating) activity, treatment, Gene Expression Monitoring, Cidofovir Anhydrous, Transcriptome Profiling, Analyses, mRNA, Transcriptome Profilings, PHK, XLG, Phk, Transcriptomics, GS-504, Differential Displays, Transcript Expression, Transcriptome Analysis, Transcriptome Analyses, Treatments, Monitoring, Cidofovir Sodium, Gene Expression Analysis, PYK, HPMPC, Sodium Salt, ATP:phosphorylase-b phosphotransferase activity, Gene Expression Analyses, Therapeutic, disease management, Therapies, Treatment, Expression Analysis, Expression AnalysesHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManfalseHomo sapiensGene expression profiling of cidofovir treatment and resistance inHeLa, HaCaT, and PHK cells2025-09-242014-02-11PRJNA170506GSE3929396062682441623702334