ENAGenomicsRutgers Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA170931Mus musculusAnaysis of the response to different therapeutic agents at the transcriptional level. The design of the experiment allows to determine how the comnination target therapy (Rapamycin + PD0325901) treatment shifted the transcriptome towards a less aggressive or even a wild type phenotype. It also allows exploring the molecular changes involved in the transition from a non metastatic to a metastatic prostate cancer mouse model. Overall design: Total RNA obtained form vehicle treated Nkx3.1CE2/+ Ptenf/f BrafCA/+ (n=3), combinatorial Rapamycin and PD0325901 treated Nkx3.1CE2/+ Ptenf/f BrafCA/+ (n=3) and vehicle treated intact Nkx3.1CE2/+ Ptenf/f (n = 6) prostate. Please contact Cory Abate-Shen (cabateshen@columbia.edu) and Jingqiang Wang (jw2639@columbia.edu) for questions about the submission.xref:PubMed:22836754ENACG10798, hereditary prostate cancer, cancer of the prostate, sm-e, PTEN, dm/myc, dmyc1, Prostate Neoplasms, GLM2, l(1)G0139, Neoplasms, familial, DPTEN, Sm-E, DmelCG10798, dPten, MYC, Myc, pten, dMyc, dMYC, Prostate Cancers., MHAM, dpten, c-Myc, anon-WO03040301.171, c-MYC, PTEN3, MYCC, Dm, SME, PTEN1, EG:BACN5I9.1, CWS1, AI463227, Prostatic Cancer, Neoplasm, Prostatic Cancers, NOS, AA120551, B-raf, TEP1, bHLHe57, myc, dPTEN, mMyc, Cancer of Prostate, activation, l(1)G0354, c-myc, Mmac, Drives, 10q23del, CG5671, sme, dm/dMyc, MMAC1, l(1)G0359, AA387315, C87398, Dmyc, DMYc, b-raf, Cancers, A130070J02Rik, d-myc, PTENa, B-Raf, cancer of prostate, DmelCG5671, HYPT11, D-Myc, Prostate Neoplasm, 9930012E13Rik, DEC, Prostatic Neoplasm, Cancer of the Prostate, C230098H17, RNCMYC, Braf-2, Braf2, B430203M17Rik, Prostatic, prostate cancer, PC, D6Ertd631e, dMyc1, MRTL, bHLHe39, BZS, Prostate Cancer, dmyc, AA473386, Prostate, 2310035O07Rik, CancerMus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscarisfalseMus musculusB-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer2025-09-242014-02-11PRJNA170931GSE391901009022836754