{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR534/SRR534599/SRR534599.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR534/SRR534600/SRR534600.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR534/SRR534598/SRR534598.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR534/SRR534602/SRR534602.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR534/SRR534597/SRR534597.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR534/SRR534601/SRR534601.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Memorial Sloan-Kettering Cancer Center"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA172189"],"scientific_name":["Human gammaherpesvirus 4","human gammaherpesvirus 4"],"tag":["pathogen","pathogen:virus","xref:PubMed:22901543"],"long_description":["Epstein-Barr Virus (EBV), which is associated with multiple human tumors, persists as a minichromosome in the nucleus of B-lymphocytes and induces malignancies through incompletely understood mechanisms. Here, we present a large-scale functional genomic analysis of EBV. Our experimentally generated nucleosome positioning maps and viral protein binding data were integrated with over 700 publicly available high-throughput sequencing data sets for human lymphoblastoid cell lines mapped to the EBV genome. We found that viral lytic genes are coexpressed with cellular cancer-associated pathways, suggesting that the lytic cycle may play an unexpected role in virus-mediated oncogenesis. Host regulators of viral oncogene expression and chromosome structure were identified and validated, revealing a role for the B-cell-specific protein Pax5 in viral gene regulation and the cohesin complex in regulating higher order chromatin structure. Our findings provide a deeper understanding of latent viral persistence in oncogenesis and establish a valuable viral genomics resource for future exploration. Overall design: Six sequencing experiments were performed. One EBNA1 ChIP-seq was controlled with IgG ChIP-seq. Two MNase-seq biological replicates were each conrolled by input seq using the same cells subjected to MNase digestion."],"repository":["ENA"],"classification":["viruses"],"additional_accession":[]},"is_claimable":false,"name":"Human gammaherpesvirus 4","description":"EBNA1 ChIP-seq and MNase-seq in EBV-positive MUTU cell lines","dates":{"last_updated":"2025-09-24","first_public":"2013-05-31"},"accession":"PRJNA172189","cross_references":{"GEO":["GSE39913"],"taxon":["10376"],"PubMed":["22901543"]}}