{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["NIH/NEI/NCCAM"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA172725"],"scientific_name":["Mus musculus"],"long_description":["T follicular helper (Tfh) cells play a pivotal role in germinal center reactions, which requires Bcl6 transcription factor. To analyze their relationships with other effector T cell lineages and their stability in vivo, we developed and analyzed a new Bcl6 reporter mouse alone or together with other lineage reporter systems. Assisted with genome-wide transcriptome analysis, we show substantial plasticity of T cell differentiation in the early phase of immune response. At this stage, CXCR5 appears to be expressed in a Bcl6-independent manner. Once Bcl6 is highly expressed, Tfh cells can persist in vivo and some of them develop into memory cells. Together, our results indicate Bcl6 as a bona fide marker for Tfh polarized program. Overall design: Three group of samples, with 2 biological replicates within each group and total of 6 samples were analyzed."],"tag":["xref:PubMed:22987803"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Bcl6 expression specifies the T follicular helper cell program in vivo","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA172725","cross_references":{"GEO":["GSE40068"],"taxon":["10090"],"PubMed":["22987803"]}}