{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics","Multiomics"],"center_name":["Institute of Experimental Genetics, Helmholtz Zentrum Muenchen"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA174341"],"scientific_name":["Mus musculus"],"tag":["xref:PubMed:23622239","xref:PubMed:18372191"],"long_description":["Evolution of the mammalian brain encompassed a remarkable increase in size of cerebral cortex, including tangential and radial expansion, but the mechanisms underlying these key parameters are still largely unknown. Here, we identified the novel DNA associated protein TRNP1 as a regulator of cerebral cortical expansion in both these dimensions. Gain and loss of function experiments in the mouse cerebral cortex in vivo demonstrate that high Trnp1 levels promote neural stem cell self-renewal and tangential expansion, while lower levels promote radial expansion resulting in a potent increase in the generation of intermediate progenitors and outer radial glial cells resulting in folding of the otherwise smooth murine cerebral cortex. Remarkably, TRNP1 expression levels exhibit regional differences also in the cerebral cortex of human fetuses anticipating radial or tangential expansion respectively. Thus, the dynamic regulation of TRNP1 is critical to regulate tangential and radial expansion of the cerebral cortex in mammals. Overall design: We performed gene expression microarray analysis on embryonic mouse cerebral cortex derived from Trnp1 knockdown and control animals."],"repository":["ENA"],"description_synonyms":["brain cortex, cortex of cerebral hemisphere, Controlling, Allocortices, preventive therapy, Trnp, reference sample, Cortex Cerebrus, FATE, Cerebral Cortices, Cortical, prophylaxis, Paleocortex, Cortical Plates, Archipalliums, 2300002D11Rik, prevention, C1orf225, TNRP, preventive measures, cortical plate (CTXpl), cortical plate (areas), Cortex, CT43., control, Periallocortex, Periallocortices, Plate, pallium of the brain, Allocortex, Cortex Cerebri, cortex cerebri, Cerebral, cortex cerebralis, prevention and control, Archipallium, Paleocortices, Controlled, Cortical Plate"],"name_synonyms":["Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscaris"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"TRNP1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA174341","cross_references":{"GEO":["GSE40582"],"taxon":["10090"],"PubMed":["23622239","18372191"]}}