{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Pathology and Immunology, Washington University School of Medicine"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA176145"],"scientific_name":["Mus musculus"],"tag":["xref:PubMed:23555752"],"long_description":["Type 1 diabetes (T1D) is an autoimmune disease triggered by T cell reactivity to protein antigens produced by the β-cells. Here we present a chronological compendium of transcriptional profiles from islets of Langerhans isolated from non-obese diabetic (NOD) mice ranging from 2 wks up to diabetes and compared to controls. Parallel analysis was made of cellular components of the islets. Myeloid cells populated the islets early during development in all mouse strains. This was followed by a type I interferon signature detectable at 4-6 wks of age only in diabetes susceptible mice. Concurrently, CD4 T cells were found within islets, many in contact with intra-islet antigen presenting cells. Early cellular signs of islet reactivity were detected by six wks. By 8 wks, NOD islets contained all major leukocytes populations and an inflammatory gene signature. This work establishes the natural transcriptional signature of T1D and provides a resource for future research. Overall design: 57 RNA samples isolated from the pancreatic islets of langerhans of experimental mice: 2-18 wk old non-obese diabetic (NOD) and newly diabetic NOD were compared to controls: NOD.RAG-/-, B6.g7 and C57BL/6. There were 3 or 6 biological replicates per condition. All mice were female. All data was normalized using RMA in Arraystar. Data table includes normalized probe intensity for every probe."],"repository":["ENA"],"description_synonyms":["T1DM, Ketosis-Prone Diabetes Mellitus, Diabetes Type 1, T cell activation, Juvenile diabetes, T1D, Juvenile Onset, Diabete, determination, Type I Diabetes, Insulin Dependent Diabetes Mellitus 1, T-lymphocyte activation, Brittle, uncontrolled, T-cell activation., Diabetes mellitus type 1 (disorder), DIABETES MELLITUS TYPE 01, Insulin Dependent Diabetes, DMI UNSPF UNCNTRLD, Ketosis Prone, type I diabetes, Juvenile-Onset, insulin-dependent diabetes mellitus, Autoimmune Diabete, Insulin dependent diabetes mellitus, Diabetes mellitus type I, Insulin-Dependent, chemical analysis, Insulin-dependent diabetes, Juvenile onset diabetes mellitus, 1, not stated as uncontrolled, immune mediated diabetes, insulin dependent diabetes, Type I, with unspecified complication, Sudden Onset, Autoimmune, Mellitus, type I diabetes mellitus, Juvenile Onset Diabetes, Sudden-Onset, diabetes mellitis type I, Autoimmune Diabetes, IDDM, Insulin-Dependent Diabetes Mellitus, IDDM - Insulin-dependent diabetes mellitus, T lymphocyte activation, Diabetes mellitus type 1, Type I diabetes, Sudden-Onset Diabetes, Sudden-Onset Diabetes Mellitus, Diabetes mellitus type I [insulin dependent type] [IDDM] [juvenile type], Juvenile Diabetes, diabetes mellitis type 1, Type 1, Ketosis-Prone, type 1 diabetes, Brittle Diabetes Mellitus, Juvenile-Onset Diabetes, Diabetes Mellitus, Type 1 Diabetes, Insulin-Dependent Diabetes Mellitus 1, assay, Interferon, Diabetes, juvenile diabetes, Juvenile-Onset Diabetes Mellitus, Type 1 Diabetes Mellitus, DMI UNSPF NT ST UNCNTRLD, Insulin Dependent"],"name_synonyms":["Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscaris"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Transcriptional analysis of type 1 diabetes reveals an interferon signature that precedes T cell activation","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA176145","cross_references":{"GEO":["GSE41203"],"taxon":["10090"],"PubMed":["23555752"]}}