{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR867/SRR867211/SRR867211.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR867/SRR867213/SRR867213.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR867/SRR867214/SRR867214.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR867/SRR867212/SRR867212.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"strain":["LT2"],"omics_type":["Genomics"],"center_name":["Uppsala University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA203730"],"scientific_name":["Salmonella enterica subsp. enterica serovar Typhimurium str. LT2"],"long_description":["To evolve bacterial resistance to antimicrobial peptides during a simple laboratory experiment. We succeed in isolating antimicrobial peptide (AMP) resistant Salmonella typhimurium LT2 mutants by serially passaging several independent bacterial lineages in progressively increasing concentrations of LL-37, CNY100HL and Wheat Germ Histones. Significant AMP resistance developed in 15/18 independent bacterial lineages. Our data suggests that resistance to antimicrobial peptides can develop rapidly through mechanisms that confer cross-resistance to several AMPs."],"tag":["pathogen:priority","pathogen:bacterium","pathogen"],"classification":["bacteria"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Salmonella enterica subsp. enterica serovar Typhimurium str. LT2","description":"Mechanisms and Fitness Costs of Resistance to Antimicrobial Peptides LL-37, CNY100HL and Wheat Germ Histones","dates":{"last_updated":"2025-09-24","first_public":"2013-05-31"},"accession":"PRJNA203730","cross_references":{"taxon":["99287"]}}