ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR867/SRR867211/SRR867211.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR867/SRR867213/SRR867213.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR867/SRR867214/SRR867214.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR867/SRR867212/SRR867212.fastq.gzprimaryOK200LT2GenomicsUppsala Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA203730Salmonella enterica subsp. enterica serovar Typhimurium str. LT2To evolve bacterial resistance to antimicrobial peptides during a simple laboratory experiment. We succeed in isolating antimicrobial peptide (AMP) resistant Salmonella typhimurium LT2 mutants by serially passaging several independent bacterial lineages in progressively increasing concentrations of LL-37, CNY100HL and Wheat Germ Histones. Significant AMP resistance developed in 15/18 independent bacterial lineages. Our data suggests that resistance to antimicrobial peptides can develop rapidly through mechanisms that confer cross-resistance to several AMPs.pathogen:prioritypathogen:bacteriumpathogenbacteriaENAfalseSalmonella enterica subsp. enterica serovar Typhimurium str. LT2Mechanisms and Fitness Costs of Resistance to Antimicrobial Peptides LL-37, CNY100HL and Wheat Germ Histones2025-09-242013-05-31PRJNA20373099287