ENAGenomicsSingapore Immunology Networkhttps://www.ebi.ac.uk/ena/browser/view/PRJNA212754Homo sapiensThe tumor suppressor protein p53 functions to regulate diverse cellular processes including apoptosis, cell cycle, senescence and metabolism. Act as a master transcription factor, it can transcriptionally regulate the gene expression of many downstream target genes. p53 is frequently mutated in cancer by single nucleotide/amino acid substitutions at the DNA binding domain that result in a mutant form of p53 protein and usually loses its DNA binding and transcriptional regulation abilities. In this study, we performed gene expression analysis using Affymetrix Exon Array ST1.0 platform to assess the transcriptome of wildtype p53 and 6 loss-of-function p53 mutants in p53null HCT116 cells. Overall design: 8 samples were analyzed as a group. pcDNA3.1 empty construct was served as a control experiment.xref:PubMed:23965983ENAHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern Manbeta-Tub60D, beta[[3]]-Tub, CG10873, DmelCG17117, dp53, Dmbeta3, Dm-HTH, HCT116, p50, p53, BETA 60D, prac, beta3t, beta3-Tub, Mini Exon, 143391_i_at, beta3 TU, LFS1, betaTub3, Cell, Tp53, l(3)05745, Xp53, 3t, HCT116 cell, DMP53, bbl, p53/tubulin, Mini-Exon, Dmp53, bfy, beta[[3]] tubulin, anon-EST:Liang-2.13, Tub60D, HTH, Hth, CG33336, beta-tub, 1323/07, HCT-116, clone 2.13, BCC7, exonic region, Mini-Exons, D.m.BETA-60D, beta-Tub6D, dmp53, DmelCG33336, D-p53, beta60C, Exon, CG3401, p50/tubulin., beta3Tub, beta3TUB, T, DmP53, Dm-P53, l(3)86Ca, 1422/04, beta3, dtl, Tub, DTB3, B3t, Meis1, DmelCG3401, hth1, Trp53, hth2, Dp53, HCT 116, betatub60D, P53, betaTub60C, p44, microarray, bhy, beta3-tubulin, HCT-116 cell, beta[[3]]-tubulin, TRP53, CG17117, CG31325, betaTub, p50/tubulinfalseHomo sapiensExon Array Expression Profiling of HCT116 (p53null) cells transfected with wildtype p53 and 6 p53 mutants2025-09-242014-02-11PRJNA212754GSE49046960623965983