{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Research Group of Pain and Neuroscience, East-West Medical Research Institute, Kyung Hee University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA214887"],"scientific_name":["Mus musculus"],"long_description":["To characterize both short- and long-term (7 days and 28 days) gene expression profiling differences between control and MPTP-treated retina, we determined levels of gene expression using microarray analysis and real-time PCR. We found 60 genes relatively regulated in retinas treated with MPTP for 7 days (26 up-regulated and 34 down-regulated), whereas 54 genes were regulated in retinas treated with MPTP for 28 days (18 up-regulated and 36 down-regulated) when compared with the non-treated retina in each control groups. Total 26 annotated differently expressed genes were chosen for further validation by quantitative real-time PCR, and 4 genes in the 7-day treatment group (Clec2e Dio2 Hmcn1 Rlbp1) and 3 genes in the 28-days treatment group (Pnmt Tmem121 Ssxb3) were confirmed. Overall design: Male C57BL/6 mice were randomly divided into four treatment groups (n= 6 in each group): the 7 days and 28 days saline-injection (control) groups (C-7 and C-28, respectively), and 7 days and 28 days MPTP-injection groups (M-7 and M-28, respectively). 4 retinas for 1 samples (1 gene chip), (4 experimental group × 2 samples of each experimental group = total 8 samples)."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Microarray analysis of gene expression profile in MPTP-treated mouse retina: Comparative analysis of short-and long-term gene regulation","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA214887","cross_references":{"GEO":["GSE49783"],"taxon":["10090"]}}