ENAGenomicsMultiomics413 Stellar Chance Lab, University of Pennsylvaniahttps://www.ebi.ac.uk/ena/browser/view/PRJNA219056Homo sapiensxref:PubMed:24218456In this study we compared the effects of ALK inhibitor on the gene expression, activation of cell signaling pathways, and functional properties of cells derived from a patient with Anaplastic Large Cell Lymphoma. we used microarrays to map the genome-wide gene expression patterns in ALK+TCL cells in response to ALK inhibition. Overall design: The ALK+TCL Sudhl-1 cell line was treated in triplicates with the ALK inhibitor, CEP-14083, or the compound's solvent for 6 h. The isolated RNA was reverse-transcribed, biotin-labeled, and hybridized to the U133 Plus 2.0 array chips (Affymetrix). Microarray data were normalized using the MAS5 algorithm and analyzed using Partek GS (Partek).ENAfalseHomo sapiensExpression of SUDHL-1 cell line treated by ALK inhibitors2025-09-222014-02-11PRJNA219056GSE50803960624218456