{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Frances Sladek Lab, Cell Biology and Neuroscience, UC Riverside"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA223179"],"scientific_name":["Homo sapiens"],"long_description":["Statin-induced gene expression differences observed in LCLs may be influenced by their transformation, and thus differ from those observed in native B-cells. To assess this possibility, we prepared LCLs and purified B-cells from the same donors, and compared mRNA profiles after 24hr incubation with simvastatin (2µM) or sham buffer. Overall design: We prepared LCLs and purified B-cells from the same donors, and compared mRNA profiles after 24hr incubation with simvastatin (2µM) or sham buffer. Genes involved in cholesterol metabolism were similarly regulated between the two cell types under both the statin and sham treated conditions, and the statin-induced changes were significantly correlated."],"tag":["xref:PubMed:24179175"],"repository":["ENA"],"name_synonyms":["Human, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern Man"],"description_synonyms":["Infectious Mononucleosis Viruses, B Cells, B Lymphocytes, Burkitt's Lymphoma Virus, B cell, Infectious, Gene, B-Cell, HMG CoA Reductase, Hydroxymethylglutaryl CoA Reductase Inhibitors, E-B Virus, Hydroxymethylglutaryl CoA Reductase Inhibitor, Herpesvirus, Human, B-Lymphocyte Count., B Cell, Epstein-Barr Virus, Statin, Epstein Barr Virus, Hydroxymethylglutaryl-CoA, Inhibitors, BLYCE, Burkitt Lymphoma Virus, Hydroxymethylglutaryl-CoA Reductase Inhibitor, Mononucleosis Viruses, E-B Viruses, Mononucleosis Virus, Hydroxymethylglutaryl-Coenzyme A Inhibitors, Burkitts Lymphoma Virus, Hydroxymethylglutaryl CoA, Burkitt, Bursa-Dependent Lymphocyte, Gene Expressions, B-Lymphocytes, Bursa-Equivalent Lymphocyte, EBV, Expressions, Statins, E B Virus, Human Herpesvirus 4, Hydroxymethylglutaryl-CoA Inhibitors, B-Cell Lymphocytes, Burkitt Herpesvirus, Reductase Inhibitor, B-Cells, Reductase Inhibitors, HHV-4, HMG-CoA Reductase, Hydroxymethylglutaryl-CoA Reductase, B lymphocyte, HMG-CoA, HMG CoA Reductase Inhibitor, HMG CoA, B-Lymphocyte, Hydroxymethylglutaryl-Coenzyme A, B-Cell Count, Infectious Mononucleosis Virus, Herpesvirus 4 (gamma), Expression, Lymphoma Virus, HMG-CoA Reductase Inhibitor, Hydroxymethylglutaryl Coenzyme A, HMG-CoA Reductase Inhibitors, HMG CoA Reductase Inhibitors, HMG-CoA Statins"],"additional_accession":[]},"is_claimable":false,"name":"Homo sapiens","description":"Statin induced changes in gene expression in EBV-transformed and native B-cells","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA223179","cross_references":{"GEO":["GSE51444"],"taxon":["9606"],"PubMed":["24179175"]}}