ENAGenomicsCellular and Molecular Biology, University Health Networkhttps://www.ebi.ac.uk/ena/browser/view/PRJNA232595Homo sapiensxref:PubMed:24487029Microarray analysis was performed at the UHN Microarray Centre (UHNMAC, Ontario, Canada) using Illumina HumanHT-12 v4 BeadChip with 500 ng of total RNA prepared by RNeasy mini kit (QIAGEN, Cat. No. 74104). Samples from HCC1954 cells with 3-day treatment of TBK1-II at 4 uM were used to compare with vehicle-treated controls. Microarray data was processed and normalized by lumi package from BioConductor in R with Quantile Method. Difference between the samples were calculated by Bayesian statistic using limma package from BioConductor in R to obtain Moderated T value for subsequent Pathway analysis. Overall design: Total RNA extracted from HER2+ HCC1954 cells after 3 days treatment of TBK1-II inhibitor compared with vehicle controlENAErbb-2, Breast Carcinoma, Human Mammary Neoplasm, primary breast cancer, Carcinoma, malignant tumor of the breast, Breast Carcinomas, "breast neoplasm" EXACT [MTH:120], Neoplasms, HER-2|neu, inhibitor of NF-kappaB kinase activity, IKBKB, mKIAA3023, IKBKA, STK12, TBK1, mammary neoplasm, Mammary Cancers, Human Mammary Neoplasms, MLN19, nak, Tumor, "breast tumor" EXACT [NCI2004_11_17:C2910], Human, CD340, Breast Malignant Neoplasm, CHUK, Breast Malignant Tumor, Kiaa3023, RRG6, "neoplasm of breast (disorder)" EXACT [SNOMEDCT_2005_07_31:126926005], Mammary Carcinomas, Breast Tumor, T2K, Neoplasm, NGL, Human Mammary Carcinoma, "mammary tumor" EXACT [CSP2005:2016-0671], NOS, breast tumor, cancer of the breast, HER-2/neu, Malignant Neoplasm of Breast, c-neu, Carcinomas, BC, Mammary Neoplasms, malignant neoplasm of breast, inhibitor of NFkappaB kinase activity, Human Mammary, Breast Neoplasm, c-erbB2, Mammary Neoplasm, HER-2, Mammary Carcinoma, Human Mammary Carcinomas, TANK-binding kinase 1 activity, AI462036, Cancers, Breast Malignant Neoplasms., "mammary neoplasm" RELATED [], ATP:IkappaB protein phosphotransferase activity, Cancer of the Breast, MLN 19, GEP6, IKK, IKK-2, breast cancer, IKK-1, cancer of breast, Malignant Tumor of Breast, t2k, Mammary, Mammary Cancer, Breast Tumors, Breast Cancer, Breast Malignant Tumors, 1200008B05Rik, TKR1, Cancer of Breast, Breast, mammary cancer, NAK, AW048562, cancer, mammary tumor, HER2, ikappaB kinase activity, breast, Neu, NEU, Tumors, CancerHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManfalseHomo sapiensshRNA kinome screen identifies TBK1 as therapeutic target for HER2+ breast cancer2025-09-242014-02-11PRJNA232595GSE53658960624487029