{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Second Military Medical University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA242798"],"scientific_name":["Rattus norvegicus"],"long_description":["To further investigate the potential molecular basis of the protective effects of MASM on irradiation (6.5Gy) damage, gene expression analysis was conducted on rats liver tissues using microarrays. Pre-treatment with MASM prevented differential expression of 53% (766 genes) of 1445 genes differentially expressed in response to radiation. Pathway enrichment analysis indicated that these genes were mainly involved in a total of 21 pathways, such as metabolic pathways, pathways in cancer, and MAPK signaling pathway. Overall design: The rats were randomly assigned to one of the three following treatment groups (10-12 animals per group): normal control, radiation and MASM dose (30 mg/kg body weight/day) + radiation. MASM dissolved in double distilled water were administered intragastrically to the male animals for 3 consecutive days before irradiation. Radiation induced gene expression in rat liver was measured at 24 hours after 6.5 Gy exposure."],"tag":["xref:PubMed:27196884"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Rattus norvegicus","description":"Matrine derivative 1b(MASM) offers radioprotection and modulates acute lethal total-body irradiation-induced alterations of gene expression","dates":{"last_updated":"2025-09-24","first_public":"2014-03-28"},"accession":"PRJNA242798","cross_references":{"GEO":["GSE56263"],"taxon":["10116"],"PubMed":["27196884"]}}