{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Neurology, Stanford University School of Medicine"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA251527"],"scientific_name":["Mus musculus"],"long_description":["Comparison of gene expression changes in Ptch-deficient mouse medulloblastoma cell line SmoWT-MB upon treatment with SMOi GDC-0449 or BETi JQ1. The hypothesis is that they can both inhibit the expressions of Hh signaling target genes in this Hh-driven tumor cell line. Overall design: Total RNA from JQ1 or GDC-0449 treated SmoWT-MB cells in comparison with DMSO treated cells"],"tag":["xref:PubMed:24973920"],"repository":["ENA"],"name_synonyms":["Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscaris"],"description_synonyms":["Bret, Regulations, Ptpb2, 1-carboxy-N, N-Trimethylglycine, Epigenetic, Formal Social Control, DEP-1, N, UNQ26, UNQ262/PRO299, bet, Control, Betaine, AI450271, Scc-1, Byp, Controls, Epigenomic, Social Controls, Social, Trimethylammonioacetate, trimethylglycine., Social Control, Trimethylaminoacetate, BET, trimethylglycocoll, Bet, acidol, N-trimethylammonioacetate, 2-N, (trimethylammoniumyl)acetate, regulation, N-trimethylammonio acetate, PTPbeta2, Epigenetics, Scc1, RPTPJ, Regulation, Formal Social Controls, CD148, N-trimethylmethanaminium inner salt, abromine"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Targeting the epigenetic regulation of Hedgehog transcriptional output through BET bromodomain inhibition","dates":{"last_updated":"2025-09-24","first_public":"2014-06-04"},"accession":"PRJNA251527","cross_references":{"GEO":["GSE58185"],"taxon":["10090"],"PubMed":["24973920"]}}