ENAGenomicsMultiomicsUrology, University of Texas Health Science Center at San Antoniohttps://www.ebi.ac.uk/ena/browser/view/PRJNA252018Homo sapiensNQO1 silencing by a specific shRNA against NQO1 increased migration and hormone-independent survival in hormone-dependent human prostate cancer cells LNCaP. Genome wide array revealed that NQO1 blockade significantly upregulated pro-inflammatory mediators (e.g., IL-32, CCL2, IL-8, IL-17C, IL-10RA, CXCR2, CXCR7, NOS3) associated with prostate tumorigenesis. Overall design: Two-condition experiment, control vs. NQO1 knockdown LNCaP cells. Biological replicates: 3 control replicates, 3 NQO1 knockdown replicates.xref:PubMed:25125658ENAHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManNAD(P)H:quinone oxidoreductase activity, signalling., quinone reductase activity, biological signaling, phylloquinone reductase activity, DHQU, NMORI, naphthoquinone reductase activity, reduced NAD(P)H dehydrogenase activity, dehydrogenase, NAD(P)H2 dehydrogenase (quinone), quinone) activity, azoreductase activity, NAD(P)H dehydrogenase activity, NADH-menadione reductase activity, vitamin K reductase activity, NAD(P)H:(quinone-acceptor)oxidoreductase activity, NMOR1, NAD(P)H-quinone oxidoreductase activity, menadione reductase activity, NQO1, Nmo1, menadione oxidoreductase activity, NAD(P)H-quinone dehydrogenase activity, flavoprotein NAD(P)H-quinone reductase activity, signalling process, NAD(P)H(2) dehydrogenase (quinone) activity, diaphorase activity, signaling process, reduced nicotinamide adenine dinucleotide (phosphate, QR1, Naphthoquinone reductase activity, vitamin-K reductase activity, NAD(P)H: menadione oxidoreductase activity, DTD, p-benzoquinone reductase activity, DT-diaphorase activity, reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity, NAD(P)H menadione reductase activity, Dia4, DIA4, viologen accepting pyridine nucleotide oxidoreductase activity, single organism signalingfalseHomo sapiensNQO1 regulates inflammatory signaling2025-09-242014-08-28PRJNA252018GSE58336960625125658