ENAGenomicsVML, Institute of Surgical Research, Oslo University Hospitalhttps://www.ebi.ac.uk/ena/browser/view/PRJNA259334Homo sapiensxref:PubMed:26292663Gene knockdown of NAT12/NAA30 led to decreased proliferation, sphere forming ability and mitochondrial hypoxia tolerance in the GSC T65 culture. Intracranial transplantation of these cells into SCID mice showed that the decreased NAT12/NAA30 expression correlated with the prolonged animal survival and reduced tumor size Overall design: Total RNA isolated from GSC cultures featuring NAT12/NAA30 gene knock-down (shRNA) was compared to total RNA from non-silencing control GSC cultures (NS-shRNA).ENAbeta[[3]]-Tub, DmelCG17117, dp53, 2610315D21Rik, p50, FKBP12-rapamycin complex-associated protein, CG5092, p53, Deficiencies, 143391_i_at, beta3 TU, mak3p, Grade IV, l(2)k03905, Astrocytomas, LFS1, betaTub3, l(2)k17004, Tp53, l(3)05745, DmTOR, Oxygen Deficiency, Oxygen Deficiencies, DMP53, responsivity, bbl, glioblastoma, Dmp53, RAFT1, TOR, Mammalian target of rapamycin, anon-EST:Liang-2.13, nat12, Giant Cell Glioblastomas, Hypoxia, DmelCG8274, reactivity, 1323/07, grade IV adult astrocytic tumor, Bx34, clone 2.13, BCC7, non-developmental growth of a unicellular organism, D.m.BETA-60D, beta-Tub6D, dmp53, p50/tubulin., T, DmP53, 1422/04, metabolic process resulting in cell growth, flat, tor, Tpr, TPR, Giant Cell Glioblastoma, dtor, Astrocytoma, 5730533P17Rik, Oxygen, Glioblastoma Multiforme, B3t, DmelCG3401, Trp53, Dp53, grade IV adult Astrocytic tumor, betaTub60C, beta3-tubulin, Grade IV Astrocytoma, beta[[3]]-tubulin, TRP53, CG17117, Frap1, NAT12P, CT24817, dTOR, dTor, Mak3p, FK506-binding protein 12-rapamycin complex-associated protein 1, beta-Tub60D, Mechanistic target of rapamycin, grade IV adult astrocytic tumour, CG10873, Dmbeta3, Dm-HTH, NAT12, mak3, metabolism resulting in cell growth, BETA 60D, prac, beta3t, beta3-Tub, C14orf35, FRAP1, FRAP2, mTOR, Giant Cell, FRAP/TOR, Nat12, DmelCG5092, Xp53, 3t, NAA30, adult glioblastoma multiforme, cell expansion, Anoxia, 2.7.11.1, primary glioblastoma multiforme, non-developmental cell growth, p53/tubulin, bfy, beta[[3]] tubulin, RAPT1, Tub60D, HTH, Hth, AW322455, glioblastoma multiforme, CG33336, beta-tub, Glioblastoma, 4930487N19Rik, spongioblastoma multiforme, AI447922, Rapamycin and FKBP12 target 1, DmelCG33336, D-p53, Glioblastomas, beta60C, GBM, Hypoxemia, CG3401, CT24745, beta3Tub, beta3TUB, Rapamycin target protein 1, Dm-P53, l(3)86Ca, AI327068, beta3, FRAP, dtl, Tub, DTB3, Meis1, hth1, Deficiency, CT16317, hth2, Grade IV Astrocytomas, betatub60D, CG8274, 5092, MTOR, P53, p44, bhy, response, Anoxemia, CG31325, betaTub, MAK3Human, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManfalseHomo sapiensKnockdown of NAT12/NAA30 decreases glioblastoma stem cell growth and tumorigenicity by regulating hypoxia response, p-MTOR (Ser2448) and p53 pathway2025-09-242015-11-25PRJNA259334GSE60706960626292663