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Sidow, Pathology, Stanford University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA266316"],"scientific_name":["Mus musculus"],"long_description":["We profiled genome-wide gene expression of 170 individual mid-gestation (embryonic day 11.5) whole mouse embryos derived from a 2-generation interspecies mouse cross and asked to what extent genetic variation drives four important parameters of regulatory architecture: allele-specific expression (ASE), imprinting, trans-regulatory effects, and maternal effect. The inbred strain C57BL/6J and wild-derived inbred strain CAST/EiJ were used in reciprocal crosses to generate F1 embryos. F1 progeny were backcrossed to C57BL/6J in reciprocal crosses to generate 154 N2 embryos. We employed a backcross design, in which N2 offspring have genotypically distinct parents, to enable comparison of gene expression for offspring from each side of the reciprocal cross. Our findings demonstrate that genetic variation contributes to widespread gene expression differences during mammalian embryogenesis. Overall design: Transcriptome analysis of E11.5 mouse embryos: 16 F1 embryos from reciprocally crossed C57BL/6J and CastEi/J parents and 154 N2 embryos from reciprocal backcross of F1s to the C57BL/6J parent."],"tag":["xref:PubMed:25871848"],"repository":["ENA"],"description_synonyms":["Embryonic, Presumptive, Embryo, Prenatal Structures, developmental tissue, embryonic organism, Gene Expressions, embryo, plant germ, Presumptive Structure, Embryos, Prenatal, Embryonic Structure, GRO:0005343, Gene, Expression, Presumptive Structures., developing organism, Expressions, Structure, Prenatal Structure"],"name_synonyms":["Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscaris"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Constraint and divergence of global gene expression in the mammalian embryo","dates":{"last_updated":"2025-09-24","first_public":"2015-04-16"},"accession":"PRJNA266316","cross_references":{"GEO":["GSE62967"],"taxon":["10090"],"PubMed":["25871848"]}}