{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR168/000/SRR1687090/SRR1687090.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR168/009/SRR1687089/SRR1687089.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Laboratory Of Biochemistry of Nucleic Acids, ICBFM SB RAS"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA269015"],"scientific_name":["Mus musculus"],"tag":["xref:PubMed:29108266"],"long_description":["Purpose: To study the alteration of whole transcriptome of Lewis lung carcinoma (LLC) cells after the decreasing of malignant properties of tumor by treatment of tumor-bearing mice with RNase A. Methods: Whole transcriptome profile of Lewis lung carcinoma before and after RNase A treatment were generated by deep sequencing using SOLiD 5.5. The sequence reads were mapped by Bioscope 1.3 software, differential expression was evaluated by Cufflinks v.2.0.1 package. Results: Difference in expression was found for 966 genes. Conclusions: Our study represents the first detailed analysis of alteration of transcriptome of Lewis lung carcinoma after the decrease of malignant prtoperties of the tumor (proliferation and invasion) by RNase A. Overall design: Whole transcriptome profile of Lewis lung carcinoma before and after RNase A treatment were generated by deep sequencing using SOLiD 5.5."],"repository":["ENA"],"description_synonyms":["Lewis lung carcinoma, Mus musculus, Laboratory Mice., Lewis Lung Carcinoma, Laboratory, Swiss, Mus domesticus, mouse, Swiss Mouse, mouse <Mus musculus>, House Mice, Swiss Mice, Lung Carcinoma, House Mouse, Cell, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscaris, whole transcriptome, House, Mus, Mus musculus domesticus, Mouse, Lewis, house mouse, Mice, Laboratory Mouse"],"name_synonyms":["Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscaris"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Whole transcriptome of Lewis lung carcinoma cells of Mus musculus","dates":{"last_updated":"2025-09-24","first_public":"2014-12-03"},"accession":"PRJNA269015","cross_references":{"GEO":["GSE63758"],"taxon":["10090"],"PubMed":["29108266"]}}