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However, how the genome-wide binding patterns of these regulators are modulated during B-lineage development remains to be determined. Here, we found that in lymphoid progenitors the chromatin remodeler Brg1 specified the B cell fate. In committed pro-B cells Brg1 regulated Igh locus contraction and controlled c-Myc expression to modulate the expression of genes that regulate ribosome biogenesis. In committed pro-B cells Brg1 also suppressed a pre-B lineage-specific pattern of gene expression. Finally, we found that Brg1 acted mechanistically to establish B cell fate and modulate cell growth by facilitating access of lineage-specific transcription factors to poised enhancer repertoires. Overall design: 8 ATAC-Seq samples from sorted ALP and BLP (duplicates, control and Brg1-deleted), 4 ATAC-Seq samples from cultured pro-B cells (duplicates, control and Brg1-deleted), 2 Ikaros ChIP-seq samples (performed in Rag1-/- pro-B cells and in E2A-/- pre-pro-B cells), 1 Brg1 ChIP-seq sample and accompanying Input sample (both in Rag1-/- pro-B cells), 4 RNA-Seq samples from cultured pro-B cells (duplicates, control and Brg1-deleted), 6 RNA-Seq samples from cultured Rag1-/- pro-B cells (triplicates, control and Brg1-knock down)."],"repository":["ENA"],"description_synonyms":["BRG1, Brg1, B-cell, B Cells, MRD16, SWI2, B Lymphocytes, Bursa-Dependent Lymphocytes, non-developmental growth of a unicellular organism, B cell, snf2, snf2b, brg1, BAF190, snf2l4, Bursa-Equivalent Lymphocyte, metabolic process resulting in cell growth, BAF190A, b2b508.1Clo, b2b692Clo, SW1|SNF, X-brg1, SNF2, baf190, SNF2L4, snf2-beta, cell expansion, SPAC29A4.21, RTPS2, snf2lb, B lymphocyte, SW1/SNF, B-Lymphocyte, snf2l, non-developmental cell growth, SNF2LB, HP1-BP72, rtps2, B-lymphocyte, metabolism resulting in cell growth., swi2, hSNF2b, SNF2beta"],"name_synonyms":["Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscaris"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth","dates":{"last_updated":"2025-09-24","first_public":"2015-05-15"},"accession":"PRJNA278629","cross_references":{"GEO":["GSE66978"],"taxon":["10090"],"PubMed":["25985234"]}}