ENAGenomicsProf. Johannes Loffing, Institute of Anatomy, University of Zurichhttps://www.ebi.ac.uk/ena/browser/view/PRJNA280721Mus musculusIn vitro studies identified TBC1D4 as an regulator of renal ion and water transporting proteins. However, TBC1D4-deficient mice did not show a defective renal salt and water homeostasis. With microarray analysis we aimed to decipher compensatory mechanisms in TBC1D4-deficient mice which might mask the renal phenotype already on transciptomic levels. Overall design: We used and compared mRNA of COPAS-sorted and -enriched distal convoluted tubule (DCT)-cells, known to express TBC1D4 at high levels, of 8-week old male homogenous C57/Bl6 mice of TBC1D4-deficient and wild-type mice.xref:PubMed:26336159ENAMus musculus, 3.4.22.-, AS160, 5930406J04Rik, Caspase-14 subunit p10, A930035N22, AV295684, Laboratory, Swiss, mice, Mus domesticus, As160, mouse, Swiss Mouse, CASP14, House Mice, Swiss Mice, mini-ICE, Caspase-14 subunit p19, CASP-14, MICE, House Mouse, domesticus, Laboratory Mice, Concept, Kidneys, Role Concept, Roles, House, Mus, Role Concepts, Mini-ICE, Role, Concepts, Mus musculus domesticus, Mouse, house mouse, Mice, Laboratory Mouse, Mus musculus., NIDDM5Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscarisfalseMus musculusRole of TBC1D4 in mouse kidneys: Identification of compensatory mechanisms in the DCT of TBC1D4-deficient mice2025-09-242015-04-11PRJNA280721GSE677011009026336159