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Aberrantly high FOXP1 expression is frequently observed in diffuse large B cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma, being associated with poor prognosis. Here, by gene expression microarray [GSE51382] and quantitative RT-PCR analysis upon ectopic overexpression of FOXP1 in primary human memory B cells (MBCs) and B-cell lines, combined with chromatin immunoprecipitation-sequencing (ChIP-seq), we established that FOXP1 directly represses expression of PRDM1, IRF4, and XBP1, transcriptional master regulators of plasma cell (PC) differentiation. In accordance, FOXP1 is prominently expressed in primary human naive and MBCs but expression strongly decreases during plasma PC differentiation. Moreover, as compared to IgM+ MBCs, IgG+ MBCs combine lower expression of FOXP1 with an enhanced intrinsic PC differentiation propensity, and constitutive (over)expression of FOXP1 in B cell lines and primary human MBCs represses their ability to differentiate into PCs. Taken together, our data indicate that proper control of FOXP1 expression plays a critical role in PC differentiation, whereas aberrant overexpression of FOXP1 might contribute to lymphomagenesis by blocking terminal B cell differentiation. Overall design: OXP1 ChIP-seq profile in primary human memory B cells (MBCs) and B-cell lines"],"tag":["xref:PubMed:26289642","xref:PubMed:25267198"],"repository":["ENA"],"description_synonyms":["RNA polymerase II core promoter proximal region sequence-specific binding, T-cell leukemia, B Cells, B Lymphocytes, AGL4, B cell, B-Cell, zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, homeobox 1, Factor, SEPALLATA 2, metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity, Transcription Factor, fkh1b, transcription factor activity, B Cell, zinc ion regulated core promoter proximal region sequence-specific DNA binding, AI461938, QRF1, RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor activity, BLYCE, sequence-specific distal enhancer binding RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, KNOTTED1-like homeobox gene 5, AW494214, F14P3.4, Transcription, hspc215, Factors, Bursa-Dependent Lymphocyte, B-Lymphocytes, 3110052D19Rik, F14P3_4, F10N7_150, xlfoxp1, Bursa-Equivalent Lymphocyte, B-Lymphocyte Count, metal ion regulated core promoter proximal region sequence-specific binding, 12CC4, hFKH1B, 12cc4, qrf1, copper ion regulated core promoter proximal region sequence-specific binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, B-lymphoma cell., Transcription factor, F10N7.150, 4932443N09Rik, B-Cell Lymphocytes, B-Cells, B lymphocyte, RNA polymerase II proximal promoter sequence-specific DNA binding, B-Lymphocyte, B-Cell Count, copper ion regulated proximal promoter sequence-specific DNA binding, copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, AGAMOUS-like 4, zinc ion regulated proximal promoter sequence-specific DNA binding, sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity, metal ion regulated sequence-specific DNA binding, metal ion regulated proximal promoter sequence-specific DNA binding, TRANSCRIPTION FACTOR, RNA polymerase II distal enhancer sequence-specific binding"],"name_synonyms":["Human, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern Man"],"additional_accession":[]},"is_claimable":false,"name":"Homo sapiens","description":"The forkhead transcription factor FOXP1 profile in B-cells and B-cell lymphoma cell lines","dates":{"last_updated":"2025-09-24","first_public":"2015-05-20"},"accession":"PRJNA284282","cross_references":{"GEO":["GSE69009"],"taxon":["9606"],"PubMed":["25267198","26289642"]}}