ENAGenomicsSmith Bldg, Medicine, Harvard Medical Schoolhttps://www.ebi.ac.uk/ena/browser/view/PRJNA284285Mus musculusxref:PubMed:26982501RasGRP4 is required for CD117+ DCs to optimally induce certain NK cell-dependent immune responses in vivo and in vitro in response to LPSRasGRP4 expressed in DCs played an important role on NK cell IFN-γ secretion . We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated or down-regulated genes between the two DCs from WT and RasGRP4 mice respectively upon LPS stimulation. Overall design: CD117+splenocytes were extracted from WT and RasGRP4 KO mice spleens aged 9-12 weeks and plated in 6-well plates with 1ug/mL of LPS for 0h,6h,12h,24h and 48h repectively for RNA extraction and hybridization on Affymetrix microarrays. Time course.ENA3.4.22.-, proto-oncogene c-Kit, p145 c-kit, Laboratory, Mus domesticus, CASP14, mouse, Tr-kit, mini-ICE, CASP-14, VWS1, PPS1, House Mouse, PBT, Gsfsco1, House, Mus, Mini-ICE, SCO5, Mus musculus domesticus, VWS, lip pit syndrome, SCO1, KIT, Gsfsow3, SCFR, Gsfsco5, Mice, SOW3, tyrosine-protein kinase Kit, Mus musculus, Fdc, c-KIT, Tyrosine-protein kinase Kit, Ly87, Caspase-14 subunit p10, Swiss, mice, Lps, LPS, OFC6, Swiss Mouse, PPS, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, House Mice, Swiss Mice, Caspase-14 subunit p19, W, CD117, Ran|M1, MICE, Laboratory Mice, domesticus, Ran/M1, lipopolysaccharides, Proto-oncogene c-Kit, 2.7.10.1, Piebald trait protein, C-Kit, Ssm, cleft lip and/or palate with mucous cysts of lower lip, Bs, Mouse, Sl, PIT, Rasl2-8., Laboratory MouseMus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscarisfalseMus musculusExpression data of CD117+ splenocytes from C57BL/6 WT and RasGRP4 KO mice upon LPS stimulation2025-09-242015-05-20PRJNA284285GSE690111009026982501