{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Cellular & Molecular Biology, CIB-CSIC"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA285780"],"scientific_name":["Escherichia coli K-12"],"long_description":["RepA-WH1 is a synthetic bacterial prionoid, i.e., a protein that aggregates as amyloid in bacteria leading to cell death The purpose of this approach was to outline the pathways of cytotoxicity linked to RepA-WH1 expression from the set of genes induced/repressed in an Escherichia coli strain with reduced genome (MDS42) Overall design: Transcription profiles in cells expressing the mildly-citotoxic RepA-WH1(∆N37)-mCherry aggregates were subtracted from the profiles for cells expressing the acutely-cytotoxic A31V amyloid aggregates. This approach was intended to supress the contribution from genes related to the general, non-specific pathways of the stress response to aggregation (i.e., quality control of proteostasis), thus highlighting those specific for RepA-WH1 cytotoxicity."],"tag":["pathogen:priority","pathogen:bacterium","pathogen","xref:PubMed:28421043"],"classification":["bacteria"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Escherichia coli K-12","description":"Expression in E. coli of hyper- and hypo-amyloidogenic RepA-WH1 variants","dates":{"last_updated":"2025-09-24","first_public":"2024-04-04"},"accession":"PRJNA285780","cross_references":{"GEO":["GSE69517"],"taxon":["83333"],"PubMed":["28421043"]}}