ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR205/000/SRR2052650/SRR2052650.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR205/006/SRR2052646/SRR2052646.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR205/007/SRR2052647/SRR2052647.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR205/002/SRR2052652/SRR2052652.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR205/003/SRR2052653/SRR2052653.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR205/009/SRR2052649/SRR2052649.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR205/001/SRR2052651/SRR2052651.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR205/008/SRR2052648/SRR2052648.fastq.gzprimaryOK200GenomicsBenaroya Research Institutehttps://www.ebi.ac.uk/ena/browser/view/PRJNA285954Homo sapiensxref:PubMed:26826243Innate lymphoid cell (ILC) subsets that mirror helper T cells in their effector cytokine profiles have recently emerged as central players in both homeostatic and inflammatory conditions. Like their Th1, Th2 and Th17/Th22 helper T cell counterparts, ILC subsets are categorized based on their expression of specific transcription factors and effector cytokines: group 1 ILC (ILC1) express T-bet and IFN-γ group 2 ILC (ILC2) express GATA-3 and type 2 effector cytokines such as IL-13 and IL-5 and group 3 ILC (ILC3) express RORgt and the cytokines IL-22 and/or IL-17. Under this nomenclature, natural killer (NK) cells and lymphoid tissue inducers (LTi) are considered ILC1 and ILC3, respectively. ILC1 contain both CD4+ and CD4- populations, but whether this phenotypic characteristic reflects functional differences between these two populations is unknown. These studies examine the gene expression profiles of CD4+ vs CD4- ILC1 in a cohort of healthy control subjects. Overall design: ILC subsets were isolated from the peripheral blood of healthy control subjects. cDNA was isolated and amplified from sorted populations, and gene expression was analyzed by RNAseqENAL3T4, Gene Expressions, T-cell surface antigen T4/Leu-3, determination, T-cell surface antigen T4|Leu-3, T-cell differentiation antigen L3T4, chemical analysis, T-cell surface glycoprotein CD4, Ly-4, CD4, T-cell surface glycoprotein CD4., Gene, Expression, assay, CD4mut, ExpressionsHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManfalseHomo sapiensGene expression analysis of CD4+ and CD4- ILC1 subsets by RNAseq2025-09-242015-06-06PRJNA285954GSE69596960626826243