{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Laboratory of Immunity and Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA290082"],"scientific_name":["Mus musculus"],"tag":["xref:PubMed:26320657"],"long_description":["The intestinal epithelial barrier plays a critical role in the mucosal immunity. However, it remains largely unknown how the epithelial barrier is maintained after damage. Here we show that FGF2 synergizes with IL-17A to induce genes for repairing of damaged epithelium. Deficiency of FGF2 or IL-17A resulted in impaired epithelial proliferation, increased pro-inflammatory microbiota outgrowth, and consequently worse pathology in a DSS-induced colitis model. Overall design: Mouse primary intestinal epithelial cells left untreated (UN) or stimulated for 6 hr with IL-17A (50 ng/ml), FGF2 (5 ng/ml), or both (IL-17A plus FGF2)."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"FGF2 cooperates with IL-17A to promote intestinal epithelium wound healing","dates":{"last_updated":"2025-09-24","first_public":"2015-07-18"},"accession":"PRJNA290082","cross_references":{"GEO":["GSE70993"],"taxon":["10090"],"PubMed":["26320657"]}}