{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Neurogenetics, Psychiatry and Neurology, UCLA"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA302291"],"scientific_name":["Mus musculus"],"long_description":["Disability or death secondary to intracerebral hemorrhage (ICH) is attributed to blood lysis, liberation of iron and generation of oxidative stress. Iron chelators bind free iron and prevent neuronal death induced by oxidative stress and disability due to ICH, but the mechanisms remain unclear. Here we show that the hypoxia-inducible factor prolylhydroxylase (HIF PHD) family of iron-dependent oxygen sensors is an effector of iron chelation in abrogating ICH-induced death. Molecular reduction of the three HIF PHD isoforms in mouse striatum improves functional recovery following ICH. A low molecular weight, hydroxyquinoline inhibitor of the HIF PHDs, which we call adaptaquin, reduces neuronal death and behavioral deficits following ICH in distinct rodent models. Unexpectedly, adaptaquin protects from oxidative death by suppressing ATF4- dependent prodeath gene expression rather than by activating a HIF-dependent prosurvival pathway. Overall design: Adaptaquin treated neurons"],"tag":["xref:PubMed:26936506"],"repository":["ENA"],"description_synonyms":["inhibitors, Brain, deceased, Oxygen 16, CREB-2, Intracranial hemorrhage, Biocatalysts, Atf-4, inhibitor, E-948, enzyme activity, 8O, Unspecified intracranial hemorrhage, INTRACRANIAL HEMORR NOS, Cardiac Death, Hemorrhages, End-Of-Life, oxygen, TXREB, Cardiac, dioxygene, dATF-4, Sauerstoff, oxigeno, post-mortem, Posterior Fossa Hemorrhage., CREB2, Near-Death Experience, NOS, l(2)crc, oxygene, Brain Hemorrhages, E948, Death, OXYGEN MOLECULE, Atf4, antagonists, 929, DmelCG8669, O2, Disauerstoff, dioxygen, death, HEMORRHAGE INTRACRANIAL, enzymes, Determination of Death, Intracranial haemorrhage NOS, Hemorrhage, Intracranial Hemorrhages, O, Oxygen-16, inhibiteur, C|ATF, End Of Life, Ire1, Intracranial Hemorrhage, ATF-4, Intracranial hemorrhage (disorder), Intracranial, Oxygen, TAXREB67, Enzyme, inhibidor, [OO], antagonists and inhibitors, intracranial hemorrhage NOS (disorder), Biocatalyst, CG8669, Posterior Fossa Hemorrhages, ATF4/crc, E 948, molecular oxygen, Dioxygen, Posterior Fossa, Intracranial haemorrhage, Brain Hemorrhage"],"name_synonyms":["Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscaris"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Adaptaquin is an inhibitor of oxygen-sensing prolyl-hydroxylase domain enzymes that abrogates ATF4-dependent death and improves outcomes from brain hemorrhage","dates":{"last_updated":"2025-09-24","first_public":"2016-01-01"},"accession":"PRJNA302291","cross_references":{"GEO":["GSE75048"],"taxon":["10090"],"PubMed":["26936506"]}}