{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR310/009/SRR3107189/SRR3107189_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR310/007/SRR3107187/SRR3107187_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR310/009/SRR3107189/SRR3107189_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR310/008/SRR3107188/SRR3107188_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR310/007/SRR3107187/SRR3107187_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR310/008/SRR3107188/SRR3107188_2.fastq.gz"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"strain":["3D7, Dd2"],"center_name":["Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA308455"],"scientific_name":["Plasmodium falciparum"],"long_description":["Drug resistance in Plasmodium falciparum is an important public health burden since it reverses the malaria control achieved so far. Understanding the mechanism of drug resistance will help us to develop novel drug/vaccine targets for malaria treatment. In the present study, we have used the whole transcriptome sequencing to characterize the transcriptional difference between chloroquine sensitive and resistant P. falciparum strains (3D7 and Dd2). The differential gene expression between these strains was analyzed to understand their phenotypic properties like drug sensitivity, immune evasion and pathways involved."],"tag":["xref:EuropePMC:PMC4872366","pathogen:protozoan","pathogen"],"classification":["protozoa"],"repository":["ENA"],"description_synonyms":["insensitive, determination, Sprain, Plasmodium, Gene, chloroquinum, Khingamin, RNA-seq., Arechine, Bemaphate, Resoquine, sensitive, chemical analysis, Strain, 1, Whole Transcriptome Shotgun Sequencing, Nivaquine B, Aralen, Sprains, sensitivity, Sanoquin, Arequin, N(4)-(7-chloro-4-quinolinyl)-N(1), Chloroquine, Gene Expressions, resistant, Plasmodium (Laverania) falciparum, chloroquine, Chingamin, Sulphate, Reumachlor, Chloroquine Sulfate, Expressions, Capquin, allergic reaction, Chlorochin, N1-diethyl-, 4-Pentanediamine, falciparums, 4-pentanediamine, cloroquina, Artrichin, Expression, assay, Strains, Chloroquine Sulphate, N(1)-diethyl-1, malaria parasite P. falciparum, N4-(7-chloro-4-quinolinyl)-N1, Plasmodium falciparums, Strains and Sprains, Sulfate, Nivaquine"],"name_synonyms":["DD, akr1c2, snRNP2, Sprain, 2-diol dehydrogenase, Plasmodium, srxy8, AKR1C-pseudo, Dihydrodiol dehydrogenase|bile acid-binding protein, CG1249, strain, SRXY8, mcdr2, hakrd, Dihydrodiol dehydrogenase 2, DmelCG1249, hbab, Strain, HAKRD, Trans-1, Chlordecone reductase homolog HAKRD, DD2, dd2, cultivar, Type III 3-alpha-hydroxysteroid dehydrogenase, Sprains, DD-2, Plasmodium (Laverania) falciparum, BcDNA:LD03002, 1.3.1.20, MCDR2, BABP, dD2, 3-alpha-HSD3, TDD, ecotype, babp, ddh2, HBAB., snRNP D2, DD|BABP, falciparums, 1.-.-.-, Strains, DDH2, malaria parasite P. falciparum, Plasmodium falciparums, 2-dihydrobenzene-1, 1.1.1.357, Strains and Sprains"],"additional_accession":[]},"is_claimable":false,"name":"Plasmodium falciparum strain:3D7, Dd2","description":"Comparative gene expression analysis of chloroquine sensitive and resistant strains of Plasmodium falciparum using RNA-Seq","dates":{"last_updated":"2025-09-24","first_public":"2016-04-30"},"accession":"PRJNA308455","cross_references":{"taxon":["5833"]}}