{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Biostatistics and Bioinformatics Unit, IRB Barcelona"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA325477"],"scientific_name":["Homo sapiens"],"long_description":["Metastasis is the leading cause of cancer-related deaths. For most human cancers, the identity of the cells that initiate and promote metastasis is still unknown, hampering our ability to develop therapies to prevent or inhibit the spread of tumour cells to distant sites. Using an orthotopic model of human oral squamous cell carcinoma (OSCC), we have now identified a subpopulation of CD44bright cells within the primary lesion with the highest potential to develop lymph node and lung metastasis. This population is slow-cycling, expresses high levels of the receptor CD36 at the cell membrane and relies on fatty acid metabolism to thrive in lymph nodes and bronchoalveolar environments. Importantly, inhibition of CD36 by either shRNA or neutralizing monoclonal antibodies severely impairs metastatic spread of primary OSCC patient samples and established cell lines. Further underscoring its importance, CD36 overexpression in poorly disseminating tumours confers an aggressive metastatic behaviour. Analyses of public gene expression data indicate that the presence of the signature-defining CD36+ cells also strongly correlates with a poor prognosis in patients with lung SCC, ovarian cancer, bladder cancer, or luminal breast cancer. By identifying metastasis-promoting cells and then targeting them with CD36 inhibition, novel anti-metastatic therapies could be developed for patients with these types of tumours. Overall design: 3 (LN2 #1#2#3)+4(PT1 #2#3#4#5) biological replicates were included. From each biological replicate, 2 independent populations were sorted (CD36+ and CD36-)."],"tag":["xref:PubMed:27974793"],"repository":["ENA"],"description_synonyms":["Saturated Fatty, acido graso, SCARB3, Cd36l1, Colony Forming Unit, Esterified Fatty Acids, Saturated, Collagen type I receptor, acidos grasos, CD36 antigen-like 2, Metastasis, CD36 antigen-like 1, Metastases, Progenitor Cells, Colony-Forming Units, Progenitor Cell, GPIIIB, Hdlq1, Neoplasm Metastases, neoplasm metastasis, Fettsaeuren, Cla1, BDPLT10, CD36, Cell, CD36 and LIMPII analogous 1, cancer metastasis, mSR-BI, AI120173, Metastase, LGP85, Fettsaeure, Platelet glycoprotein IV, Colony-Forming Unit, Stem Cell, acides gras, PASIV, LIMP II, PAS-4, Neoplasm, Mother Cells, Scarb3, Saturated Fatty Acids, Esterified Fatty Acid, PAS IV, Adipocyte membrane protein, GP3B, Progenitor, Fatty acid transport protein, Esterified, Mother Cell, SRBI, Platelet collagen receptor, Acid, SR-BI, tumor cell migration, Fatty Acids, Fatty Acid, Leukocyte differentiation antigen CD36, Saturated Fatty Acid, Stem, Esterified Fatty, CLA-1, Aliphatic, CHDS7, Mother, Aliphatic Acid, metastasis, Colony Forming Units, D5Ertd460e, acide gras, Fatty acid translocase, Scavenger receptor class B member 2, thrombospondin receptor-like 1, Cla-1., fatty acids, Aliphatic Acids, Hlb398, SRB1, Srb1, GP4, SR-B1, Cells, Lysosome membrane protein II, Glycoprotein IIIb, Thrombospondin receptor, GPIV, 85 kDa lysosomal membrane sialoglycoprotein, FAT, Fat, tumor metastasis"],"name_synonyms":["Human, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern Man"],"additional_accession":[]},"is_claimable":false,"name":"Homo sapiens","description":"Targeting metastasis stem cells through the fatty acid receptor CD36","dates":{"last_updated":"2025-09-24","first_public":"2017-04-19"},"accession":"PRJNA325477","cross_references":{"GEO":["GSE83276"],"taxon":["9606"],"PubMed":["27974793"]}}