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and Exploratory Data Analysis, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Rochehttps://www.ebi.ac.uk/ena/browser/view/PRJNA325783Homo sapiensxref:PubMed:28325303Molecular phenotyping quantifies expression of pathway reproter genes by next-generation sequencing of pre-defined amplicons. We applied the technology to quantify pathway-level impact of ASOs to PTECs in the presence and absence of exogeneous EGF. Overall design: Five ASOs, each in three concentrations, and vehicle controls were added to the cell culture of PTEC-TERT1 cells either in the presence or in the absence of exogeneous EGF. Molecular phenotyping was performed 6 hours later. Three biological replicates were performed for each conditionENATransitional Epithelial Cell, Transitional, Adenomatous Epithelial Cell, Squamous Cells, Adenomatous Epithelial Cells, Squamous Cell, proximal kidney tubule, Epithelial Cell, Glandular Epithelial Cell., renal proximal tubule, Glandular Epithelial Cells, Adenomatous, Adenomatous Epithelial, Glandular Epithelial, Squamous, Glandular, Oligonucleotide, Transitional Epithelial, proximal tubule, Cell, proximal convoluted tubule, Squamous Epithelial Cells, Cuboidal Glandular Epithelial Cells, Epithelial Cells, Transitional Epithelial Cells, Cells, Columnar Glandular Epithelial Cells, Squamous Epithelial Cell, Squamous Epithelial, kidney proximal tubule, EpithelialHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManfalseHomo sapiensMolecular phenotyping of antisense oligonucleotides (ASOs) in immortalized proximal tubule epithelial cells (PTEC-TERT1)2025-09-242017-04-19PRJNA325783GSE83392960628325303