ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/007/SRR4011397/SRR4011397.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/003/SRR4011403/SRR4011403.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/009/SRR4011399/SRR4011399.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/005/SRR4011405/SRR4011405.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/007/SRR4011407/SRR4011407.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/003/SRR4011413/SRR4011413.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/000/SRR4011400/SRR4011400.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/004/SRR4011414/SRR4011414.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/002/SRR4011392/SRR4011392.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/005/SRR4011395/SRR4011395.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/008/SRR4011408/SRR4011408.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/001/SRR4011411/SRR4011411.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/008/SRR4011398/SRR4011398.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/000/SRR4011410/SRR4011410.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/002/SRR4011402/SRR4011402.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/006/SRR4011406/SRR4011406.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/009/SRR4011409/SRR4011409.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/003/SRR4011393/SRR4011393.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/001/SRR4011401/SRR4011401.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/004/SRR4011394/SRR4011394.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/002/SRR4011412/SRR4011412.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/006/SRR4011396/SRR4011396.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR401/004/SRR4011404/SRR4011404.fastq.gzprimaryOK200GenomicsHuman DNA Analysis, Technology Development, Kazusa DNA Research Institutehttps://www.ebi.ac.uk/ena/browser/view/PRJNA338161Mus musculusxref:PubMed:27798619Virus infection induces T follicular helper (TFH) and T helper 1 (TH1) cells. Although TFH cells are important in anti-viral humoral immunity, the role of TH 1 cells is still elusive. IgG2 antibodies predominate in the response to vaccination with inactivated Influenza A virus (IAV) and were responsible for protective immunity to lethal challenge with pathogenic H5N1 and pandemic H1N1 IAVs even in mice lacking TFH cells owing to B or T cell-specific ablation of the Bcl6. We demonstrate that IL-21 and IFN-γ secreted from TH1 cells were essential for greater persistence and higher titers of IgG2 protective antibodies. These results suggest that TH1 induction could be a promising strategy to induce effective neutralizing antibodies against emerging influenza viruses. Overall design: TH1 or TFH cells of wild type (WT) and conditional Bcl6-/- mice were sorted and analyzed the transcriptome using Illumina HiSeq1500.ENAhelper cell, Helper T-Lymphocyte, ZBTB27, determination, helper T-lymphocyte, T helper cell, number, zbtb27, A4, Helper Inducer, T-Lymphocyte, helper T-cell, T4 cell, presence, laz3, TYPE, Cell, LGMD2C, DAGA4, Helper T Cells, helper T cell, count in organism, znf51, T-Lymphocytes, Helper-Inducer T-Lymphocytes, Helper-Inducer T-Lymphocyte, T-Cell, Helper Cells, helper lymphocyte, CD4 cell, chemical analysis, Inducer T-Lymphocytes, Helper T Cell, ZNF51, MAM, SCG3, Helper T-Cells, Helper T-Lymphocytes, DMDA1, Helper-Inducer T-Cells, T-Cells, Helper T, Helper, Inducer Cell, Helper Inducer T Lymphocytes, helper T lymphocyte, Helper-Inducer, T-helper cell, Helper-Inducer T-Cell, T Cells, bcl5, bcl6a, DMDA, Helper T-Cell, Inducer T-Lymphocyte, Inducer, Inducer Cells, LAZ3, SCARMD2, Cells, Helper Cell., T Cell, assay, BCL5, Bcl5, BCL6A, T LymphocytesMus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscarisfalseMus musculusNext Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Bcl6-/- helper T cell Transcriptomes2025-09-242016-10-14PRJNA338161GSE853161009027798619