ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/000/SRR4031590/SRR4031590_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/000/SRR4031580/SRR4031580_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/008/SRR4031578/SRR4031578_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/009/SRR4031579/SRR4031579_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/008/SRR4031578/SRR4031578_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/009/SRR4031589/SRR4031589_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/005/SRR4031585/SRR4031585_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/009/SRR4031579/SRR4031579_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/004/SRR4031584/SRR4031584_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/007/SRR4031577/SRR4031577_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/003/SRR4031583/SRR4031583_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/001/SRR4031581/SRR4031581_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/002/SRR4031582/SRR4031582_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/001/SRR4031581/SRR4031581_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/002/SRR4031582/SRR4031582_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/003/SRR4031583/SRR4031583_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/008/SRR4031588/SRR4031588_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/000/SRR4031580/SRR4031580_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/007/SRR4031577/SRR4031577_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/006/SRR4031586/SRR4031586_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/007/SRR4031587/SRR4031587_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/007/SRR4031587/SRR4031587_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/008/SRR4031588/SRR4031588_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/006/SRR4031586/SRR4031586_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/005/SRR4031585/SRR4031585_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/000/SRR4031590/SRR4031590_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/009/SRR4031589/SRR4031589_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/004/SRR4031584/SRR4031584_1.fastq.gzprimaryOK200GenomicsCenter for Genome Analysis, ABLife, Inc.https://www.ebi.ac.uk/ena/browser/view/PRJNA338947Homo sapiensProanthocyanidins (PAs) that are naturally occurring compounds have shown the potential chemopreventive efficacy against various forms of cancers in different tumor models. To elucidate the responsible molecular mechanisms involved in antitumor therapeutic effects of PAs, the transcriptome changes of pancreatic cancer cells exposure to PAs at 3, 12 and 24h were investigated in this study. Through two biological replicate sequencing, 966, 3543 and 4944 differentially expressed genes in response to PAs exposure were detected at 3, 12 and 24h, respectively. GO and KEGG analysis showed that cell cycle checkpoints and DNA repair modulations or inhibition were the mainly mechanisms in PAs anti-cancer. Overall, this study provided novel insights into not only the first integrated overview on global gene expression in pancreatic cancer cells post PAs exposure, but also the underlying mechanisms of anti-cancer effects of PAs for chemotherapy. Overall design: Transcriptome change of PANC-1 cells post Proanthocyanidins (20 μg/ml) exposure at 3, 12 and 24h were investigated. A biological replicate sequencing was carried out.xref:PubMed:30675233xref:PubMed:30854052ENACarcinoma, Neoplasms, malignant neoplasm of body of pancreas, pancreatic neoplasm, familial, Tannins, Pancreas Cancer, Tannin, Gene, pancreas, Polymers, Pancreas Cancers, Pancreas Neoplasm, Pancreatic Neoplasm, Ca tail of pancreas, Anthocyanidin Polymers, Condensed Tannins, Ca head of pancreas, Pancreatic Cancer, Neoplasm, Pancreatic Acinar, Cell., pancreatic carcinoma, Pancreatic, Cancer of the Pancreas, Pancreatic Carcinomas, Carcinomas, malignant neoplasm of tail of pancreas, Procyanidins, pancreatic tumor, Cancer of Pancreas, Gene Expressions, Pancreatic Carcinoma, malignant neoplasm of head of pancreas, Acinar Carcinoma, Cancers, Pancreatic Cancers, Anthocyanidin, Expressions, Pancreas, Pancreatic Acinar Carcinoma, Condensed, Condensed Tannin, Ca body of pancreas, Expression, PNCA, Pancreas Neoplasms, Pancreatic Acinar Carcinomas, Acinar Carcinomas, pancreatic tumour, pancreas neoplasm, CancerHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManfalseHomo sapiensGene expression profiles in response to proanthocyanidins in pancreatic cancer cells2025-09-242019-02-09PRJNA338947GSE8561096063067523330854052