{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Jonna Frasor, Physiology and Biophysics, University of Illinois at Chicago"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA339054"],"scientific_name":["Homo sapiens"],"long_description":["Estrogen receptor α (ER) is a good prognostic marker expressed in ~75% of breast tumors. Women with ER+ tumors will receive endocrine therapy, yet ~50% will experience relapse and late recurrence ~5-20 years after primary diagnosis. The recurrent tumors are often aggressive, resistant, and metastatic. A growing body of evidence suggests that an inflammatory microenvironment and the activation of the NF-ĸB pathway are highly associated with the progression of ER+ tumors to more aggressive stages. However, it is unknown whether NF-ĸB is a driver or a consequence of aggressive ER+ disease. In order to study this, we developed multiple ER+ breast cancer cell lines expressing a Doxycycline-inducible, constitutively active form of IĸB kinase β (CA-IKKβ), a key kinase in the canonical NF-ĸB pathway. This allowed us to specifically activate the canonical arm of the NF-ĸB pathway in a controlled fashion. Overall design: Constitutively active IKK β-MCF-7 cells are treated with Estrogen (E2), Doxycycline (Dox) or E2+Dox for 72 hrs.The study includes four groups: Vehicle, E2, Dox and E2+Dox with three replicates per group."],"repository":["ENA"],"description_synonyms":["oestrogen receptor positive breast cancer, ER+ breast cancer, Phenotypes., estrogen receptor positive breast cancer, estrogen-receptor positive breast cancer"],"name_synonyms":["Human, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern Man"],"additional_accession":[]},"is_claimable":false,"name":"Homo sapiens","description":"The effect of IKKβ on estrogen receptor positive breast cancer phenotypes","dates":{"last_updated":"2025-09-24","first_public":"2016-08-18"},"accession":"PRJNA339054","cross_references":{"GEO":["GSE85683"],"taxon":["9606"]}}