{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/009/SRR4035109/SRR4035109.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/001/SRR4035111/SRR4035111.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/008/SRR4035108/SRR4035108.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR403/000/SRR4035110/SRR4035110.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Cancer Science Institute of Singapore"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA339127"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:28978570"],"long_description":["ChIP-seq analysis was performed in an adult T-cell leukemia/lymphoma cell line (TL-Om1) to analyze DNA bindings of RNA polymerase II (Pol II) after treatment with the THZ1 CDK7 inhibitor. Overall design: TL-Om1 cells were treated with control DMSO or THZ1 for 3 hours. The cells were crosslinked with formaldehyde for 10 min. DNA was enriched by chromatin-immunoprecipitation (ChIP) and analyzed by Illumina Hiseq 4000. A sample of whole cell extract (WCE) was sequenced and used as the background to determine enrichment. ChIP was performed using an antibody against RNA polymerase II (Abcam, ab817: 8WG16)."],"repository":["ENA"],"description_synonyms":["HITS-CLIP, High Throughput Sequencing of RNA Isolated by Crosslinking Immunoprecipitation, Therapy, RNA, Ribonucleic, ChIP-Chip, Chromatin Immuno-precipitation, determination, ribose nucleic acid, Cross Linking and Immunoprecipitation Followed by Deep Sequencing, ribonucleic acids, ChIP Sequencing, CLIP-Seq, RNS, Assay for Transposase-Accessible Chromatin Using Sequencing, ChIP-PET, ChIP-Exo, C130009K11Rik, OM-1, 6230418K12Rik, yeast nucleic acid, Ribonukleinsaeure, chemical analysis, Chromatin Immunoprecipitation Sequencing-Chip, Gene Products, pentosenucleic acids, Cell., Ribonucleic acids, High-Throughput Sequencing of RNA Isolated by Crosslinking Immunoprecipitation, Non Polyadenylated, Ranbp8, RNA Gene Products, ChIA-PET, Abcc10, treatment, ribonucleic acid, Acid, Chromatin Immunoprecipitation Sequencing Chip, Chromatin Immuno precipitation Sequencing, ChIP, Chromatin Immunoprecipitation Paired End Tag, Non Polyadenylated RNA, Chromatin Immuno Precipitation Paired End Tag, Non-Polyadenylated, Cross-Linking and Immunoprecipitation Followed by Deep Sequencing, Chromatin Immunoprecipitation, Chromatin Immuno-precipitation Sequencing, Ribonucleic Acid, ChIP Exonuclease, ChIP-Seq, Treatments, Sequencing, Assay for Transposase Accessible Chromatin Using Sequencing, Non-Polyadenylated RNA, Chromatin Immunoprecipitation Paired-End Tag, MRP7, Therapeutic, Chromatin Immuno-Precipitation Paired-End Tag, ATAC-Seq, Chromatin Immunoprecipitation Sequencing-Chips, disease management, Therapies, Om1, Treatment, assay, ChIP-Exonuclease"],"name_synonyms":["Human, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern Man"],"additional_accession":[]},"is_claimable":false,"name":"Homo sapiens","description":"RNA Pol II ChIP-seq analysis after THZ1 treatment in TL-Om1 cells","dates":{"last_updated":"2025-09-24","first_public":"2017-10-07"},"accession":"PRJNA339127","cross_references":{"GEO":["GSE85693"],"taxon":["9606"],"PubMed":["28978570"]}}