ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/007/SRR4235377/SRR4235377_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/008/SRR4235368/SRR4235368_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/006/SRR4235376/SRR4235376_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/000/SRR4235370/SRR4235370_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/007/SRR4235377/SRR4235377_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/009/SRR4235369/SRR4235369_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/005/SRR4235375/SRR4235375_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/003/SRR4235373/SRR4235373_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/008/SRR4235368/SRR4235368_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/006/SRR4235376/SRR4235376_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/004/SRR4235374/SRR4235374_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/004/SRR4235374/SRR4235374_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/001/SRR4235371/SRR4235371_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/005/SRR4235375/SRR4235375_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/001/SRR4235371/SRR4235371_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/002/SRR4235372/SRR4235372_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/002/SRR4235372/SRR4235372_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/009/SRR4235369/SRR4235369_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/003/SRR4235373/SRR4235373_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR423/000/SRR4235370/SRR4235370_2.fastq.gzprimaryOK200GenomicsSystems Pharmacology and Translational Therapeutics,Institute for Immunology, University of Pennsylvaniahttps://www.ebi.ac.uk/ena/browser/view/PRJNA342526Mus musculusUpon PD-1 pathway blockade,the epigenetic landscape of exhausted cells was only minimally remodeled consistent with lineage commitment and re-exhaustion of these cells over time. Overall design: Epigenetic profiling of Exhausted T cells & examinaton of epigenetic changes associated with PD-pathway blockade by ATAC-seq using the mouse model of chronic infection with lymphocytic choriomeningitis virus (LCMV)xref:PubMed:40389726xref:PubMed:27789795ENAfalseMus musculusEpigenetic inflexibility of exhausted T cells limits durability of reinvigoration by PD-1 blockade2025-09-242016-11-02PRJNA342526GSE86797100902778979540389726