{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Chromatin & Gene Expression Group, Cancer and Genomic Sciences, University of Birmingham"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA350585"],"scientific_name":["Mus musculus"],"long_description":["The KMT2A/MLL1 lysine methyltransferase complex is an epigenetic regulator of selected developmental genes, in part through the SET-domain-catalyzed methylation of H3K4. It is essential for normal embryonic development and haematopoiesis and frequently mutated in cancer. The catalytic properties and targeting of KMT2A/MLL1 depend on the proteins with which it complexes and the post-translational protein modifications which some of these proteins put in place, though detailed mechanisms remain unclear. We have shown that KMT2A/MLL1 (both native and FLAG-tagged) and Msk1 (RPS6KA5), co-immunoprecipitated in various cell types. This experiment showed that the great majority of genes whose activity changed on KTM2A/MLL1 knockdown responded comparably to Msk1 knockdown. Overall design: A 10 array study in which KMT2A (Mll1) or MSK1 were knocked down in mouse embryonic fibroblasts. There were 3 control (mock transfected) samples, 4 KMT2A shRNA samples and 3 MSK1 shRNA samples."],"tag":["xref:PubMed:27895715"],"repository":["ENA"],"name_synonyms":["Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscaris"],"description_synonyms":["3110005L17Rik, HTRX1, Laboratory, Mll, MLL, HRX, Mus domesticus, mouse, RLPK, Gene, MLL|GAS7, MLL/GAS7, House Mouse, MLL1A, mice C57BL/6xCBA/CaJ hybrid, Cxxc7, Mus muscaris, House, Mus, Mus musculus domesticus, Mice, Embryonic, TET1-MLL, Mus musculus, 6330404E13Rik, Gene Expressions, MSK1, Msk1, Swiss, mice, CXXC7, All1, WDSTS, Swiss Mouse, ALL-1, MSPK1, House Mice, Swiss Mice, Expressions, mKIAA4050, Fibroblast., domesticus, Laboratory Mice, Mll1, MLL1, 6430520K01, AI854034, TRX1, Mouse, Expression, house mouse, Laboratory Mouse"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Comparison of gene expression changes following knockdown of KMT2A and MSK1 in mouse embryonic fibroblasts","dates":{"last_updated":"2025-09-24","first_public":"2016-10-27"},"accession":"PRJNA350585","cross_references":{"GEO":["GSE89141"],"taxon":["10090"],"PubMed":["27895715"]}}