{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR502/001/SRR5026751/SRR5026751.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR502/002/SRR5026752/SRR5026752.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR502/009/SRR5026759/SRR5026759.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR502/008/SRR5026758/SRR5026758.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR502/004/SRR5026754/SRR5026754.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR502/003/SRR5026753/SRR5026753.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR502/001/SRR5026761/SRR5026761.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR502/006/SRR5026756/SRR5026756.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR502/000/SRR5026760/SRR5026760.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR502/005/SRR5026755/SRR5026755.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR502/007/SRR5026757/SRR5026757.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR502/002/SRR5026762/SRR5026762.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Ipsen"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA354265"],"scientific_name":["Mus musculus"],"tag":["xref:PubMed:29073177"],"long_description":["Despite advances in treatment modalities, 5-year survival of OSCC has remained at ~50% for the past decades, mostly due to the high risk of developing secondary primary tumors. Early detection of OSCC represents one of the most promising approaches to improving survival. In this study, we examined the alterations of DNA methylation in early stage of oral carcinogenesis in mice induced by carcinogen dibenzo[def,p]chrysene. We identified 30 differentially methylated sites and canonical pathways that may be served as potential biomarkers for early detection of OSCC. Overall design: We analyzed the DNA methylomes from oral tissues of mice treated with dibeno[def,p]chrysene (24 nmol, 3 times per week, 5 weeks) or vehicle DMSO (n=3 per group). This animal protocol was selected based on our previous study showing maximum DNA damage induced by carcinogen while the tissues were histologically normal . Genomic DNA were extracted from oral tissues and subjected to Enhanced Reduced Representation Bisulfite Sequencing (ERRBS)."],"repository":["ENA"],"description_synonyms":["3.4.22.-, def, DNS, (Deoxyribonucleotide)n, Laboratory, Mus domesticus, Cavity, mini-ICE, CASP-14, rima oris, DJ434O14.5, House Mouse, HMG-1, Deoxyribonucleic acids, Cavitas Oris, S-tributyl trithiophosphate, Deoxyribonucleic Acid, House, AA408296, Mus musculus domesticus, Vestibule of the Mouth, Oral Cavity, Mice, Oral Cavity Proper, valve, UTP25, thymus nucleic acid, vestibulum oris, Oral, Swiss, mouth cavity, tributylphosphine oxide, Mouth Cavity Proper, S, Double Stranded, bucca, Swiss Mice, Deoxyribonucleic acid, Cavitas oris propria, adult mouth, oral vestibule, Vestibule Oris, pharyngeal valve, cavity of mouth, Double-Stranded DNA, (Deoxyribonucleotide)m, deoxyribonucleic acids, DNAn, oral fissure, DNAn+1, mouse, Double-Stranded, tribufos, (Deoxyribonucleotide)n+m, Oral region, cavitas oris, Mus, trisbutylphosphine oxide, Hmg1, Mini-ICE, anatomische Mund, cavum oris, ds-DNA, desoxyribose nucleic acid, buccal cavity, Mus musculus, S-tributyl phosphorotrithioate, butyphos, Caspase-14 subunit p10, p30, Oral part of face, mice, Swiss Mouse, House Mice, Mouth, Caspase-14 subunit p19, MICE, C1orf107, S-phosphorotrithioate, Laboratory Mice, domesticus, Def, DEF, amphoterin, c1orf107, Rima oris, ds DNA, vestibule of mouth, Desoxyribonukleinsaeure, Mouse, SBP-1, DNA, oral cavity, butifos., Laboratory Mouse, tributyl S, AW045375"],"name_synonyms":["Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscaris"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Alterations of DNA methlation in oral cavity of mice induced by dibenzo[def,p]chrysene","dates":{"last_updated":"2025-09-24","first_public":"2018-03-01"},"accession":"PRJNA354265","cross_references":{"GEO":["GSE89916"],"taxon":["10090"],"PubMed":["29073177"]}}