ENAGenomicsInternal Medicine, Toho Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA358510Homo sapiensxref:PubMed:29404483Among all the evaluated factors, only adipose tissue insulin sensitivity (assessed by clamped % suppression of serum free fatty acid), serum concentration of high molecular weight adiponectin, and plasma concentration of TCA cycle metabolites such as citric acid and cis-aconitic acid (assessed by metabolome analysis), associated significantly and positively with hepatic insulin sensitivity in NAFLD. Overall design: We analyzed the data to identify factors associated with preserved hepatic insulin sensitivity despite of hepatic steatosis. The 26 NAFLD patients with intrahepatic lipid content of >5% were divided into three groups according to the level of hepatic insulin sensitivity, as assessed by clamped % suppression of endogenous glucose production. Then, all the evaluated factors were compared between the hepatic insulin sensitive and resistant patients with comparable hepatic steatosis (n=9 vs 8, respectively).ENAfalseHomo sapiensIdentify factors associated with preserved hepatic insulin sensitivity despite of hepatic steatosis.2025-09-242017-04-19PRJNA358510GSE92746960629404483