{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["DNA-chip Development Center for Infectious Diseases, RIMD, Osaka univ."],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA359121"],"scientific_name":["Mus musculus"],"tag":["xref:PubMed:28768723"],"long_description":["Lamtor1 is a protein that is required for amino acid sensing and activation of mechanistic target of rapamycin complex 1 (mTORC1) at lysosomes. The critical role of Lamtor1 in macrophage polarization has been clarified recently. However, the role of Lamtor1 in adaptive immune system has not been investigated. Here we show that Lamtor1-deficient T cells showed markedly reduced IL-2 production, decreased mTORC1 activity, and decreased expression of purine-synthesis and lipid-synthesis enzymes. Overall design: The labeled cRNAs were hybridized on 4X44K ver.2 Agilent Whole Mouse Genome dual colour Microarrays (G4846A) in a dye swap experiment."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Essential roles of Lamtor1 in CD4+ T cell-mediated autoimmunity","dates":{"last_updated":"2025-09-24","first_public":"2017-04-19"},"accession":"PRJNA359121","cross_references":{"GEO":["GSE92946"],"taxon":["10090"],"PubMed":["28768723"]}}