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Lab, Department of Biology, University of Copenhagenhttps://www.ebi.ac.uk/ena/browser/view/PRJNA377127Homo sapiensInflammatory bowel disease (IBD) is a common and chronic gut disorder, with two subtypes: Crohn's disease (CD) and ulcerative colitis (UC), which are challenging to diagnose. The molecular pathology IBD is not well understood, and the underlying gene regulatory regions have not been comprehensively investigated. Relatedly, most IBD-associated SNPs are located in non-coding regions, and may effect gene regulation. Here, we profiled genome-wide promoter and enhancer activity in the descending colon of IBD patients. IBD-induced enhancer and promoters are highly enriched for IBD-associated SNPs, and can predict IBD diagnosis with an accuracy of 85% in an external cohort. Overall design: This experiment includes a total of 94 patients: 25 patients with active UC(UCa), 17 patients with UC in remission(UCi), 20 patients with active CD(CDa), 3 patients with CD in remission(CDi) and 29 healthy controls (Ctrl).xref:PubMed:29695774ENAInflammatory Bowel Diseases, Bowel Diseases, inflammatory bowel disease., IBD, Descending Colon, bacterial transcription, descending colon, colon descendens, Inflammatory bowel disease, site, autoimmune bowel disorder, INFLAMM BOWEL DIS, Inflammatory, transcription from bacterial-type RNA polymerase promoter, Inflammatory Bowel Disease, regionHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManfalseHomo sapiensThe transcription start site and enhancer landscape of the descending colon in inflammatory bowel disease2025-09-242018-03-16PRJNA377127GSE95437960629695774