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of Georgiahttps://www.ebi.ac.uk/ena/browser/view/PRJNA392448Campylobacter jejuniCampylobacter jejuni infections are a leading cause bacterial food-borne diarrheal illness worldwide, and Campylobacter infections in children are associated with stunted growth and therefore long-term deficits into adulthood. Despite this global impact on health and human capital, how zoonotic C. jejuni responds to the human host remains unclear. Here we use a controlled clinical trial of human infection to characterize C. jejuni transcriptional and genetic adaptations in vivo, along with a non-human primate infection model to validate our approach. C. jejuni Isolate sequencing reveals genetic and transcriptional changes that are the result of human passage in a highly controlled setting.pathogen:bacteriumpathogen:priorityxref:EuropePMC:PMC5876760pathogenbacteriaENAstrain, Sprain, Ampylobacter jejuni, Strain., cultivar, Strains, Vibrio jejuni, Campylobacter fetus subsp. jejuni, Sprains, Strains and Sprains, Vibrio hepaticus, ecotypeAcute onset, Human, Infestation and Infection, human being, Man (Taxonomy), Homo sapiens, Modern Man, Modern, Infection, Infestations and Infections, Infection and Infestation, Infections and Infestations., man, Man, Ampylobacter, humanfalseCampylobacter jejuni strain:CG8421Campylobacter adaptation during acute and persistent human infections2025-09-242018-03-11PRJNA392448197