{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR582/004/SRR5824344/SRR5824344.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR582/009/SRR5824339/SRR5824339.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR582/003/SRR5824343/SRR5824343.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR582/001/SRR5824341/SRR5824341.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR582/000/SRR5824340/SRR5824340.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR582/002/SRR5824342/SRR5824342.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Stem Cell and Cancer, Institut Municipal d'Investigacions Mèdiques, (IMIM), Hospital del Mar"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA394141"],"scientific_name":["Mus musculus"],"long_description":["We have generated a mouse model for tumor initiation carrying a mutation in APC and lacking IKKα in intestinal epithelial cells. IKKα-deficient intestinal cells primarily failed to generate adenomas, and the few adenomas arising in this background displayed a significant reduction in cell proliferation. Using an in vitro model for intestinal tumoroids (derived from adenoma initiating cells), we have performed RNA sequencing of wild type and IKKα-deficient intestinal tumoroids. This has demonstrated that epithelial IKKα controls transcription of stem cell-related genes and genes associated with proliferation and apoptosis. Overall design: RNA sequencing of IKKa WT and KO tumoroids, done in triplicates"],"tag":["xref:PubMed:29438366"],"repository":["ENA"],"name_synonyms":["Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscaris"],"description_synonyms":["3.4.22.-, D-APC1, D-APC2, D-Axin, e-apc, Laboratory, Daxin, Neoplasms, Mus domesticus, Benign Neoplasm, apc, mini-ICE, axn, CASP-14, Tumor, Malignant, House Mouse, DP3, PPP1R46, DP2, NFKBIKA, d-axin, House, DAPC, CG6193, Mus musculus domesticus, Min, BTPS2, GSK3beta, CG1451, D-APC, Ikka, Mice, dApc, dAPC, Fbxo24, Malignancy, Swiss, mAPC, Swiss Mice, Fbx24, Chuk1, CG7926, AI047805, Neoplasias, dAPC2/E-APC, AI256658, cyclosome, Malignancies, DmelCG6193, Cancer, Tumors, Ikbka, dAxin, DmelCG1451, dApc2, Malignant Neoplasm, din, l(3)S044230, E-APC, DP2.5, IKBKA, mouse, d-APC, APC2, dAXIN, Apc1, TCF16, APC1, xapc, Benign, E-APC dAPC2, Mus, apc 1, Mini-ICE, Neoplasm, apc1, axin, apc2, IKK-alpha, d-APC2, Mus musculus., dAPC2, dAPC1, AU020952, Mus musculus, Caspase-14 subunit p10, IKK1, mice, CC1, 0442/30, Swiss Mouse, initiation, Benign Neoplasms, House Mice, Caspase-14 subunit p19, Cancers, AW124434, IKKA, MICE, Dm APC2, Dm APC1, DAxin, Malignant Neoplasms, Laboratory Mice, domesticus, GS, DmelCG7926, APC, Mouse, anaphase promoting complex, other neoplasm, Laboratory Mouse, Neoplasia"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Intestinal IKKa is required for tumor initiation in APC mutant mice","dates":{"last_updated":"2025-09-24","first_public":"2018-04-19"},"accession":"PRJNA394141","cross_references":{"GEO":["GSE101415"],"taxon":["10090"],"PubMed":["29438366"]}}